Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes.
Antibiotic resistance
Bacterial cholangitis
Biliary drainage
Cancer
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
13
04
2021
accepted:
08
06
2021
pubmed:
21
8
2021
medline:
27
1
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
Pancreatic and biliary duct cancers are increasing causes of acute cholangitis (AC). We retrospectively characterize 81 cancer-associated cholangitis (CAC) compared to 49 non-cancer-associated cholangitis (NCAC). Clinical and biological presentations were similar. However, in CAC, antibiotic resistance and inadequate empirical antibiotic therapy were more frequent; more patients required ≥ 2 biliary drainages; and mortality at day 28 was higher than in NCAC. Death was associated with initial severity and CAC in a multivariate analysis. Cholangitis associated with pancreatic or biliary duct cancers requires specific empirical antimicrobial therapy; early use of biliary drainage may improve outcomes.
Identifiants
pubmed: 34415466
doi: 10.1007/s10096-021-04289-0
pii: 10.1007/s10096-021-04289-0
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-146Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M et al (2007) Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg 14:15–26. https://doi.org/10.1007/s00534-006-1152-y
doi: 10.1007/s00534-006-1152-y
pubmed: 17252293
pmcid: 2784509
Sokal A, Sauvanet A, Fantin B, de Lastours V (2019) Acute cholangitis: diagnosis and management. J Visc Surg 156:515–525. https://doi.org/10.1016/j.jviscsurg.2019.05.007
doi: 10.1016/j.jviscsurg.2019.05.007
pubmed: 31248783
Mosler P (2011) Diagnosis and management of acute cholangitis. Curr Gastroenterol Rep 13:166–172. https://doi.org/10.1007/s11894-010-0171-7
doi: 10.1007/s11894-010-0171-7
pubmed: 21207254
Singh A, Mann HS, Thukral CL, Singh NR (2014) Diagnostic accuracy of MRCP as compared to ultrasound/CT in patients with obstructive jaundice. J Clin Diagn Res JCDR 8:103–107. https://doi.org/10.7860/JCDR/2014/8149.4120
doi: 10.7860/JCDR/2014/8149.4120
pubmed: 24783094
Gigot JF, Leese T, Dereme T, Coutinho J, Castaing D, Bismuth H (1989) Acute cholangitis. Multivariate analysis of risk factors. Ann Surg 209:435–8. https://doi.org/10.1097/00000658-198904000-00008
doi: 10.1097/00000658-198904000-00008
pubmed: 2930289
pmcid: 1493983
Thompson JE, Pitt HA, Doty JE, Coleman J, Irving C (1990) Broad spectrum penicillin as an adequate therapy for acute cholangitis. Surg Gynecol Obstet 171:275–282
pubmed: 2218831
Basoli A, Schietroma M, De Santis A, Colella A, Fiocca F, Speranza V (1986) Acute cholangitis: diagnostic and therapeutic problems. Ital J Surg Sci 16:261–267
pubmed: 3557932
Schneider J, Hapfelmeier A, Thöres S, Obermeier A, Schulz C, Pförringer D et al (2016) Mortality Risk for Acute Cholangitis (MAC): a risk prediction model for in-hospital mortality in patients with acute cholangitis. BMC Gastroenterol 16:15. https://doi.org/10.1186/s12876-016-0428-1
doi: 10.1186/s12876-016-0428-1
pubmed: 26860903
pmcid: 4746925
Weber A, Schneider J, Wagenpfeil S, Winkle P, Riedel J, Wantia N et al (2013) Spectrum of pathogens in acute cholangitis in patients with and without biliary endoprosthesis. J Infect 67:111–121. https://doi.org/10.1016/j.jinf.2013.04.008
doi: 10.1016/j.jinf.2013.04.008
pubmed: 23603487
Tan M, Schaffalitzky de Muckadell OB, Laursen SB (2018) Association between early ERCP and mortality in patients with acute cholangitis. Gastrointest Endosc 87:185–92. https://doi.org/10.1016/j.gie.2017.04.009
doi: 10.1016/j.gie.2017.04.009
pubmed: 28433613
Schneider J, De Waha P, Hapfelmeier A, Feihl S, Römmler F, Schlag C et al (2014) Risk factors for increased antimicrobial resistance: a retrospective analysis of 309 acute cholangitis episodes. J Antimicrob Chemother 69:519–525. https://doi.org/10.1093/jac/dkt373
doi: 10.1093/jac/dkt373
pubmed: 24084640
Gomi H, Solomkin JS, Schlossberg D, Okamoto K, Takada T, Strasberg SM et al (2018) Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. J Hepato-Biliary-Pancreat Sci 25:3–16. https://doi.org/10.1002/jhbp.518
doi: 10.1002/jhbp.518
Miura F, Okamoto K, Takada T, Strasberg SM, Asbun HJ, Pitt HA et al (2018) Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. J Hepato-Biliary-Pancreat Sci 25:31–40. https://doi.org/10.1002/jhbp.509
doi: 10.1002/jhbp.509
Reuken PA, Torres D, Baier M, Löffler B, Lübbert C, Lippmann N et al (2017) Risk factors for multi-drug resistant pathogens and failure of empiric first-line therapy in acute cholangitis. PLoS ONE 12:e0169900. https://doi.org/10.1371/journal.pone.0169900
doi: 10.1371/journal.pone.0169900
pubmed: 28076388
pmcid: 5226732
Kiriyama S, Kozaka K, Takada T, Strasberg SM, Pitt HA, Gabata T et al (2018) Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). J Hepato-Biliary-Pancreat Sci 25:17–30. https://doi.org/10.1002/jhbp.512
doi: 10.1002/jhbp.512
Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJC, Baron EJ et al (2010) Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis Off Publ Infect Dis Soc Am 50:133–164. https://doi.org/10.1086/649554
doi: 10.1086/649554
Wu P-S, Chuang C, Wu P-F, Lin Y-T, Wang F-D (2018) Anaerobic coverage as definitive therapy does not affect clinical outcomes in community-onset bacteremic biliary tract infection without anaerobic bacteremia. BMC Infect Dis 18:277. https://doi.org/10.1186/s12879-018-3184-8
doi: 10.1186/s12879-018-3184-8
pubmed: 29902981
pmcid: 6003161
Kiriyama S, Takada T, Hwang T-L, Akazawa K, Miura F, Gomi H et al (2017) Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. J Hepato-Biliary-Pancreat Sci 24:329–337. https://doi.org/10.1002/jhbp.458
doi: 10.1002/jhbp.458
Sun G, Han L, Yang Y, Linghu E, Li W, Cai F et al (2014) Comparison of two editions of Tokyo guidelines for the management of acute cholangitis. J Hepato-Biliary-Pancreat Sci 21:113–119. https://doi.org/10.1002/jhbp.9
doi: 10.1002/jhbp.9