Immunological parameters associated with the severity of COVID-19 pneumonia in kidney transplant recipients.
COVID-19
Flow cytometry
Kidney transplantation
Lymphocytes
Natural killer cells
T cells
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
07
03
2021
accepted:
06
07
2021
pubmed:
21
8
2021
medline:
15
4
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
An outbreak of a novel respiratory disease due to coronavirus species was emerged in 2019 and named as Coronavirus Disease-2019 (COVID-19). Clinical and immunological factors affecting the course of COVID-19 in kidney transplant recipients (KTR) are not well-known. In this prospective observational study, we presented 20 KTR with COVID-19 pnemonia and examined the factors predicting the severity of COVID-19. A total of 10 KTR without COVID-19 was used as control group. Lymphocyte subsets were determined by flow cytometry. In 13/20 patients, immunophenotyping was repeated 1 week later. Mean age of the patients was 50 ± 9 years. Patients were classified as mild-moderate (oxygen saturation: SO In this pilot study, increased NK cells, activated CD8 + cells and decreased CD3 + and CD4 + cells were associated with severity of COVID-19 in KTR. Peripheral immunophenotyping of lymphocyte subtypes may provide prognostic information about the clinical course of COVID-19 in KTR.
Identifiants
pubmed: 34415473
doi: 10.1007/s11255-021-02947-y
pii: 10.1007/s11255-021-02947-y
pmc: PMC8377705
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1105-1116Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
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