Treatment of Radiation-Associated Fractures: A Critical Analysis Review.
Journal
JBJS reviews
ISSN: 2329-9185
Titre abrégé: JBJS Rev
Pays: United States
ID NLM: 101674872
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
entrez:
20
8
2021
pubmed:
21
8
2021
medline:
1
4
2022
Statut:
epublish
Résumé
Fractures that result from radiation-induced bone damage are a recognized adverse effect of radiation therapy (RT). The mechanisms of damage from RT are thought to be related to impaired vascularity, aberrations in osteoclast and osteoblast-mediated bone turnover, and compromise of cortical and trabecular microarchitecture. Treatment of radiation-associated fractures is challenging, with rates of delayed union and nonunion of >50%. Fracture management strategies, each with its own profile of risks and benefits, include prophylactic intramedullary nailing of long bones, open reduction and internal fixation with adjunctive iliac crest or vascularized fibular grafting, and endoprosthetic reconstruction.
Identifiants
pubmed: 34415860
doi: 10.2106/JBJS.RVW.20.00275
pii: 01874474-202108000-00007
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 by The Journal of Bone and Joint Surgery, Incorporated.
Déclaration de conflit d'intérêts
Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/A737).
Références
Bluemke DA, Fishman EK, Scott WW Jr. Skeletal complications of radiation therapy. Radiographics. 1994 Jan;14(1):111-21.
Dickie CI, Parent AL, Griffin AM, Fung S, Chung PW, Catton CN, Ferguson PC, Wunder JS, Bell RS, Sharpe MB, O’Sullivan B. Bone fractures following external beam radiotherapy and limb-preservation surgery for lower extremity soft tissue sarcoma: relationship to irradiated bone length, volume, tumor location and dose. Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1119-24. Epub 2009 Apr 11.
Pak D, Vineberg KA, Griffith KA, Sabolch A, Chugh R, Ben-Josef E, Biermann JS, Feng M. Dose—effect relationships for femoral fractures after multimodality limb-sparing therapy of soft-tissue sarcomas of the proximal lower extremity. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1257-63. Epub 2011 Nov 16.
Gortzak Y, Lockwood GA, Mahendra A, Wang Y, Chung PW, Catton CN, O’Sullivan B, Deheshi BM, Wunder JS, Ferguson PC. Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh. Cancer. 2010 Mar 15;116(6):1553-9.
Oh D, Huh SJ. Insufficiency fracture after radiation therapy. Radiat Oncol J. 2014 Dec;32(4):213-20. Epub 2014 Dec 30.
Asai K, Shioyama Y, Nakamura K, Sasaki T, Ohga S, Nonoshita T, Yoshitake T, Ohnishi K, Terashima K, Matsumoto K, Hirata H, Honda H. Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy: risk factors and dose-volume relationship. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):768-73. Epub 2012 Mar 23.
Helmstedter CS, Goebel M, Zlotecki R, Scarborough MT. Pathologic fractures after surgery and radiation for soft tissue tumors. Clin Orthop Relat Res. 2001 Aug;(389):165-72.
Grimer R, Judson I, Peake D, Seddon B. Guidelines for the management of soft tissue sarcomas. Sarcoma. 2010;2010:506182. Epub 2010 May 31.
Folkert MR, Casey DL, Berry SL, Crago A, Fabbri N, Singer S, Alektiar KM. Femoral Fracture in Primary Soft-Tissue Sarcoma of the Thigh and Groin Treated with Intensity-Modulated Radiation Therapy: Observed versus Expected Risk. Ann Surg Oncol. 2019 May;26(5):1326-31. Epub 2019 Jan 31.
Kondo H, Searby ND, Mojarrab R, Phillips J, Alwood J, Yumoto K, Almeida EA, Limoli CL, Globus RK. Total-body irradiation of postpubertal mice with (137)Cs acutely compromises the microarchitecture of cancellous bone and increases osteoclasts. Radiat Res. 2009 Mar;171(3):283-9.
Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, She Y, Murthy S, Ma N, Chin-Sinex HJ, Bellido TM, Bateman TA, Mendonca MS, Mohammad KS, Guise TA. Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model. J Bone Miner Res. 2015 Jul;30(7):1268-79. Epub 2015 Jun 8.
Chandra A, Lan S, Zhu J, Lin T, Zhang X, Siclari VA, Altman AR, Cengel KA, Liu XS, Qin L. PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone. 2013 Aug;55(2):449-57. Epub 2013 Mar 5.
Green DE, Adler BJ, Chan ME, Rubin CT. Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity. J Bone Miner Res. 2012 Apr;27(4):749-59.
Hui SK, Khalil A, Zhang Y, Coghill K, Le C, Dusenbery K, Froelich J, Yee D, Downs L. Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation. Am J Obstet Gynecol. 2010 Oct;203(4):353.e1-7. Epub 2010 Aug 3.
Green DE, Adler BJ, Chan ME, Lennon JJ, Acerbo AS, Miller LM, Rubin CT. Altered composition of bone as triggered by irradiation facilitates the rapid erosion of the matrix by both cellular and physicochemical processes. PLoS One. 2013 May 31;8(5):e64952.
Green DE, Rubin CT. Consequences of irradiation on bone and marrow phenotypes, and its relation to disruption of hematopoietic precursors. Bone. 2014 Jun;63:87-94. Epub 2014 Mar 5.
Oest ME, Mann KA, Zimmerman ND, Damron TA. Parathyroid Hormone (1-34) Transiently Protects Against Radiation-Induced Bone Fragility. Calcif Tissue Int. 2016 Jun;98(6):619-30. Epub 2016 Feb 4.
Damron TA, Policastro CG, Oest ME, Mann KA, Zimmerman N. Paper 27: Reduction in functional and material bone strength following radiation therapy. Presented at the 2016 Musculoskeletal Tumor Society Annual Meeting, Detroit, MI. October 6, 2016.
El Abiad JM, Raad M, Puvanesarajah V, Rao SS, Morris CD, Levin AS. Prophylactic versus postfracture stabilization for metastatic lesions of the long bones: a comparison of 30-day postoperative outcomes. J Am Acad Orthop Surg. 2019 Aug 1;27(15):e709-16.
Sambri A, Gardini L, Dalla Rosa M, Zavatta G, Keskinbora M, Ferrari C, Donati DM, Bianchi G. Femoral fracture in primary soft-tissue sarcoma of the thigh treated with radiation therapy: indications for prophylactic intramedullary nail. Arch Orthop Trauma Surg. 2020 Jul 23. [Epub ahead of print].
Zimel MN, Hwang S, Riedel ER, Healey JH. Carbon fiber intramedullary nails reduce artifact in postoperative advanced imaging. Skeletal Radiol. 2015 Sep;44(9):1317-25. Epub 2015 May 17.
Fragomen AT, Teplensky J, Robert Rozbruch S. Carbon-Fiber-Reinforced Polymer Intramedullary Nails Perform Poorly in Long-Bone Surgery. HSS J. 2019 Jul;15(2):109-14. Epub 2018 Oct 12.
Laux CJ, Villefort C, Ehrbar S, Wilke L, Guckenberger M, Müller DA. Carbon Fiber/Polyether Ether Ketone (CF/PEEK) Implants Allow for More Effective Radiation in Long Bones. Materials (Basel). 2020 Apr 9;13(7):E1754.
Loeb AE, Mitchell SL, Osgood GM, Shafiq B. Catastrophic Failure of a Carbon-Fiber-Reinforced Polyetheretherketone Tibial Intramedullary Nail: A Case Report. JBJS Case Connect. 2018 Oct-Dec;8(4):e83.
Vercio RC, Basmajian HG. Fracture of a Carbon Fiber Reinforced Intramedullary Femoral Nail. J Am Acad Orthop Surg. 2019 Jun 15;27(12):e585-8.
Cannon CP, Lin PP, Lewis VO, Yasko AW. Management of radiation-associated fractures. J Am Acad Orthop Surg. 2008 Sep;16(9):541-9.
Sternheim A, Saidi K, Lochab J, O’Donnell PW, Eward WC, Griffin A, Wunder JS, Ferguson P. Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure. Bone Joint J. 2013 Aug;95-B(8):1144-8.
Tibbo ME, Houdek MT, Bakri K, Rose PS, Sems SA, Moran SL. Outcomes of free vascularized fibular flaps for the treatment of radiation-associated femoral nonunions. J Plast Reconstr Aesthet Surg. 2020 Nov;73(11):1989-94. Epub 2020 Sep 4.
Yakoub MA, Or O, Athanasian EA, Boland PJ, Healey JH. Paper 46: Clinical Outcomes of Vascularized Fibular Graft for Treatment of Late Radiation-Induced Complications in Long Bones. Presented at the 2017 Musculoskeletal Tumor Society Annual Meeting, Denver, CO. September 29, 2017.
Kim HJ, Healey JH, Morris CD, Boland PJ. Site-dependent replacement or internal fixation for postradiation femur fractures after soft tissue sarcoma resection. Clin Orthop Relat Res. 2010 Nov;468(11):3035-40.
Mavrogenis AF, Pala E, Romantini M, Guerra G, Romagnoli C, Maccauro G, Ruggieri P. Side effects of radiation in musculoskeletal oncology: clinical evaluation of radiation-induced fractures. Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1)(Suppl 2):29-37.
Allison DC, Huang E, Ahlmann ER, Carney S, Wang L, Menendez LR. Peri-prosthetic infection in the orthopedic tumor patient. Reconstructive Review. 2014;4(3):13-7.
Callaghan CM, Hasibuzzaman MM, Rodman SN, Goetz JE, Mapuskar KA, Petronek MS, Steinbach EJ, Miller BJ, Pulliam CF, Coleman MC, Monga VV, Milhem MM, Spitz DR, Allen BG. Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents. Cancers (Basel). 2020 Aug 12;12(8):E2258.
Gerrand CH, Rankin K. Preoperative Versus Postoperative Radiotherapy in Soft-Tissue Sarcoma of the Limbs: A Randomised Trial. In: Banaszkiewicz P, Kader D, editors. Classic Papers in Orthopaedics. London: Springer; 2014.
Schwartz A, Rebecca A, Smith A, Casey W, Ashman J, Gunderson L, Curtis K, Chang YH, Beauchamp C. Risk factors for significant wound complications following wide resection of extremity soft tissue sarcomas. Clin Orthop Relat Res. 2013 Nov;471(11):3612-7. Epub 2013 Jun 28.
Stinson SF, DeLaney TF, Greenberg J, Yang JC, Lampert MH, Hicks JE, Venzon D, White DE, Rosenberg SA, Glatstein EJ. Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 1991 Nov;21(6):1493-9.
Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patel SR, Benjamin RS. Preoperative vs. postoperative radiation therapy for soft tissue sarcoma: a retrospective comparative evaluation of disease outcome. Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):482-8.
Lin PP, Schupak KD, Boland PJ, Brennan MF, Healey JH. Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer. 1998 Jun 15;82(12):2356-65.
Holt GE, Griffin AM, Pintilie M, Wunder JS, Catton C, O’Sullivan B, Bell RS. Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy. J Bone Joint Surg Am. 2005 Feb;87(2):315-9.
Livi L, Santoni R, Paiar F, Bastiani P, Beltrami G, Caldora P, Capanna R, De Biase P, Detti B, Fondelli S, Meldolesi E, Pertici M, Polli C, Simontacchi G, Biti G. Late treatment-related complications in 214 patients with extremity soft-tissue sarcoma treated by surgery and postoperative radiation therapy. Am J Surg. 2006 Feb;191(2):230-4.
Alektiar KM, Hong L, Brennan MF, Della-Biancia C, Singer S. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: preliminary results. Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):458-64. Epub 2007 Mar 23.
Rimner A, Brennan MF, Zhang Z, Singer S, Alektiar KM. Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh. Cancer. 2009 Jan 1;115(1):149-57.
Bishop AJ, Zagars GK, Allen PK, Moon BS, Lin PP, Lewis VO, Guadagnolo BA. Treatment-related fractures after combined modality therapy for soft tissue sarcomas of the proximal lower extremity: Can the risk be mitigated? Pract Radiat Oncol. 2016 May-Jun;6(3):194-200.
Wright JG. Revised grades of recommendation for summaries or reviews of orthopaedic surgical studies. J Bone Joint Surg Am. 2006 May;88(5):1161-2.