Continuous clinical improvement of mild-to-moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide-based shampoo after an initial treatment with ketoconazole.
ketoconazole
scalp microbiota
seborrheic dermatitis
selenium disulfide
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
24
06
2021
received:
07
04
2021
accepted:
22
07
2021
pubmed:
21
8
2021
medline:
25
5
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
Scalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS The main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two-phase treatment period. The scalp microbiota and clinical efficacy were investigated in 68 subjects with mild-to-moderate scalp SD after an initial one-month treatment with 2% ketoconazole, and after a 2-month maintenance phase, either with a 1% SeS Thirty one subjects in the active and 37 subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (-1.75 p < 0.05), non-adherent (-1.5, p < 0.05)) flakes and erythema (scores 1.67-0.93, p < 0.001), in an increased fungal diversity and in a significant (p < 0.005) decrease of Malassezia spp. SeS Selenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of Staphylococcus spp. in scalp SD and open possible perspectives for preventing relapses.
Identifiants
pubmed: 34416081
doi: 10.1111/jocd.14362
pmc: PMC10234447
doi:
Substances chimiques
Hair Preparations
0
Selenium Compounds
0
Ketoconazole
R9400W927I
selenium disulfide
Z69D9E381Q
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2215-2225Subventions
Organisme : Laboratoires Vichy
Informations de copyright
© 2021 L’OREAL. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
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