Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
received:
23
03
2021
accepted:
06
08
2021
entrez:
21
8
2021
pubmed:
22
8
2021
medline:
1
9
2021
Statut:
epublish
Résumé
Ghrelin, also called "the hunger hormone", is a gastric peptide hormone that regulates food intake, body weight, as well as taste sensation, reward, cognition, learning and memory. One unique feature of ghrelin is its acylation, primarily with an octanoic acid, which is essential for its binding and activation of the ghrelin receptor, a G protein-coupled receptor. The multifaceted roles of ghrelin make ghrelin receptor a highly attractive drug target for growth retardation, obesity, and metabolic disorders. Here we present two cryo-electron microscopy structures of G
Identifiants
pubmed: 34417468
doi: 10.1038/s41467-021-25364-2
pii: 10.1038/s41467-021-25364-2
pmc: PMC8379176
doi:
Substances chimiques
Ghrelin
0
Oligopeptides
0
Receptors, Ghrelin
0
growth hormone releasing hexapeptide
4H7N4I6X6A
GTP-Binding Protein alpha Subunits, Gq-G11
EC 3.6.5.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5064Informations de copyright
© 2021. The Author(s).
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