mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.
2019-nCoV Vaccine mRNA-1273
Animals
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Cell Line
Chlorocebus aethiops
Female
Humans
Macaca mulatta
Male
Mesocricetus
Primates
/ immunology
RNA, Viral
/ immunology
SARS-CoV-2
/ immunology
Spike Glycoprotein, Coronavirus
/ immunology
Vaccination
/ methods
Vero Cells
Viral Load
/ methods
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
23
06
2021
accepted:
04
08
2021
pubmed:
22
8
2021
medline:
13
10
2021
entrez:
21
8
2021
Statut:
ppublish
Résumé
B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonhuman primates received two doses of 30 or 100 µg of Moderna's mRNA-1273 vaccine, a single immunization of 30 µg, or no vaccine. Two doses of 100 µg of mRNA-1273 induced 50% inhibitory reciprocal serum dilution neutralizing antibody titers against live SARS-CoV-2 p.Asp614Gly and B.1.351 of 3,300 and 240, respectively. Higher neutralizing responses against B.1.617.2 were also observed after two doses compared to a single dose. After challenge with B.1.351, there was ~4- to 5-log
Identifiants
pubmed: 34417590
doi: 10.1038/s41590-021-01021-0
pii: 10.1038/s41590-021-01021-0
pmc: PMC8488000
mid: NIHMS1730774
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
RNA, Viral
0
Spike Glycoprotein, Coronavirus
0
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1306-1315Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400004C
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AI005030
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
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