Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation.

Adenosine Triphosphate / metabolism Apoptosis / drug effects Cell Death / drug effects Cell Line, Tumor Cocaine / adverse effects Humans Metabolic Networks and Pathways / drug effects Poly (ADP-Ribose) Polymerase-1 / metabolism Proline / metabolism Signal Transduction / drug effects Tumor Suppressor Protein p53 / metabolism
ATP Cocaine Poly(ADP-ribose) polymerase-1 Proline oxidase p53

Journal

Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 23 04 2021
accepted: 06 08 2021
pubmed: 22 8 2021
medline: 17 3 2022
entrez: 21 8 2021
Statut: ppublish

Résumé

Cocaine is a commonly abused drug worldwide. Acute as well as repeated exposure to cocaine activates persistent cellular and molecular changes in the brain reward regions. The effects of cocaine are predominantly mediated via alterations in neuronal gene expression by chromatin remodeling. Poly(ADP-ribose) polymerase-1 (PARP-1) catalyzed PARylation of chromatin has been reported as an important regulator of cocaine-mediated gene expression. PARP-1 dependent ADP-ribosylation is an energy-dependent process. In this study, we investigated the cellular energy response to cocaine-induced upregulation of PARP-1 expression. Exposure of differentiated SH-SY5Y cells to varying concentrations of cocaine resulted in the induction of PARP-1 dependent PARylation of p53 tumor suppressor. Further analysis revealed that PARylation of p53 by cocaine treatment resulted in nuclear accumulation of p53. However, induction and nuclear accumulation of p53 did not correlate with neuronal apoptosis/cell death upon cocaine exposure. Interestingly, cocaine-induced p53 PARylation resulted in the induction of proline oxidase (POX)-a p53 responsive gene involved in cellular metabolism. Given that cocaine-induced p53 PARylation is an energy-dependent process, we observed that cocaine-induced PARP-1/p53/POX axes alters cellular energy metabolism. Accordingly, using pharmacological and genetic studies of PARP-1, p53, and POX, we demonstrated the contribution of POX in maintaining cellular energy during neuronal function. Collectively, these studies highlight activation of a novel metabolic pathway in response to cocaine treatment.

Identifiants

DOI: 10.1007/s00726-021-03065-w PMID: 34417893 PMC: PMC8651605
pubmed: 34417893
doi: 10.1007/s00726-021-03065-w
pii: 10.1007/s00726-021-03065-w
pmc: PMC8651605
doi:

Substances chimiques

Tumor Suppressor Protein p53 0
Adenosine Triphosphate 8L70Q75FXE
Proline 9DLQ4CIU6V
PARP1 protein, human EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30
Cocaine I5Y540LHVR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1903-1915

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI136740
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007586
Pays : United States
Organisme : NIDA NIH HHS
ID : R24 DA036420
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI122960
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042348
Pays : United States
Organisme : National Center on Minority Health and Health Disparities
ID : U54MD007586
Organisme : NIAID NIH HHS
ID : R25 AI164610
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007593
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Sabyasachi Dash (S)

Center for AIDS Health Disparities Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA.
School of Graduate Studies and Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA.
Weill Cornell Medicine, Cornell University, New York, NY, USA.

Chandravanu Dash (C)

Center for AIDS Health Disparities Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. cdash@mmc.edu.
School of Graduate Studies and Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. cdash@mmc.edu.
Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. cdash@mmc.edu.

Jui Pandhare (J)

Center for AIDS Health Disparities Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. jpandhare@mmc.edu.
School of Graduate Studies and Research, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. jpandhare@mmc.edu.
Department of Microbiology, Immunology and Physiology, Meharry Medical College, 1005 Dr. DB Todd Jr. Blvd., Nashville, TN, 37208, USA. jpandhare@mmc.edu.
ORCID: 0000-0002-0356-064X

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Tropanes › Cocaïne › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Activation of proline metabolism maintains ATP...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Activation of proline metabolism maintains ATP...