Association of serum Gasdermin D with anti-N-methyl-D-aspartate receptor encephalitis.
Anti-N-methyl-D-aspartate receptor encephalitis
GSDMD
inflammation
pyroptosis
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
12
08
2021
received:
11
06
2021
accepted:
13
08
2021
pubmed:
22
8
2021
medline:
11
1
2022
entrez:
21
8
2021
Statut:
ppublish
Résumé
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease of the central nervous system. Gasdermin D (GSDMD) is associated with autoimmune disorders and neuroinflammatory disorders, but its role in anti-NMDAR encephalitis is unclear. In this study, we measured serum levels of GSDMD in 42 patients with anti-NMDAR encephalitis and 25 healthy controls. Of the 42 patients, 17 had follow-up evaluation of GSDMD levels and modified Rankin scale (mRS) scores at 3 months. Association of GSDMD with anti-NMDAR encephalitis and its clinical parameters were evaluated. Serum GSDMD levels were significantly higher in patients with anti-NMDAR encephalitis than in healthy controls (p = 0.002, p
Substances chimiques
Biomarkers
0
GSDMD protein, human
0
Intracellular Signaling Peptides and Proteins
0
Phosphate-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
923-930Informations de copyright
© 2021 International Society for Neurochemistry.
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