Oral epithelial dysplasia: Recognition, grading and clinical significance.
HPV
dysplasia
grading systems
malignant transformation
oral cancer
oral potentially malignant disorders
pre-cancer
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
14
07
2021
received:
07
06
2021
accepted:
31
07
2021
pubmed:
22
8
2021
medline:
30
10
2021
entrez:
21
8
2021
Statut:
ppublish
Résumé
Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on the molecular pathogenesis and histological interpretation of the features of epithelial dysplasia are described, and the use of grading systems for epithelial dysplasia is discussed. Changes to the current 2017 WHO criteria for diagnosis are proposed with emphasis on the architectural features of epithelial dysplasia. The predictive values of three-grade and binary systems are summarised, and categories of epithelial dysplasia are reviewed, including lichenoid and verrucous lesions, keratosis of unknown significance, HPV-associated dysplasia, differentiated and basaloid epithelial dysplasia. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are discussed from the pathologists' viewpoint.
Types de publication
Journal Article
Review
Langues
eng
Pagination
1947-1976Informations de copyright
© 2021 Wiley Periodicals LLC.
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