Pain differences in neurite orientation dispersion and density imaging measures among community-dwelling older adults.
Aging
Brain
Pain
White matter
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
19
02
2021
revised:
07
07
2021
accepted:
13
08
2021
pubmed:
22
8
2021
medline:
21
10
2021
entrez:
21
8
2021
Statut:
ppublish
Résumé
Neurite orientation dispersion and density imaging (NODDI) is a technique providing more detailed information on the microstructural bases of white matter. Given the previously reported white matter contributions to chronic pain, the present study aims to investigate pain-specific differences in NODDI measures across white matter tracts in a sample of community-dwelling older adults with (n = 29) and without (n = 18) chronic musculoskeletal pain. We further aimed to investigate associations between NODDI measures and clinical and experimental pain measures. As part of the Nepal study, a subset of older adults (>60 years old), underwent multiple laboratory sessions providing self-reported and experimental pain measures and a diffusion weighted neuroimaging sequence. Older adults with chronic musculoskeletal pain had a lower neurite density with less geometric complexity across a number of white matter tracts compared to older pain-free controls (corrected p's < 0.05). Lower neurite density was associated with greater self-reported pain intensity and anatomical pain sites, as well as greater experimental pain sensitivity (p's < 0.05). There were also significant pain-by-sex differences in neurite density and geometric complexity across multiple white matter tracts mainly around the hippocampus (corrected p's < 0.05). Finally, there were no pain differences with respect to extra-cellular water diffusion (corrected p's > 0.05). Our study demonstrates less geometric complexity in neurite density and architecture in chronic musculoskeletal pain, partly in a sex-dependent manner. An increased understanding of neurobiological mechanisms such as those measured by NODDI may contribute to the potential targeting of interventions in our older population suffering from chronic pain.
Identifiants
pubmed: 34418483
pii: S0531-5565(21)00302-8
doi: 10.1016/j.exger.2021.111520
pmc: PMC9091979
mid: NIHMS1783263
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111520Subventions
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG048259
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001427
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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