Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator.
Air pollution
CC16
Children
Lung function
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
29
04
2021
revised:
27
07
2021
accepted:
14
08
2021
pubmed:
23
8
2021
medline:
7
1
2022
entrez:
22
8
2021
Statut:
ppublish
Résumé
Early life exposure to air pollution can affect lung health. Previous studies have not assessed the implications of both pre- and postnatal exposure to air pollutants on lung function at repeated ages during childhood. In addition, there is the need to identify potential mediators of such effect. To longitudinally assess the association between pre- and postnatal air pollution exposure and lung function during childhood. We also aimed to explore the role of Club cell secretory protein (CC16) as a potential mediator in this association. We included 487 mother-child pairs from the INMA (INfancia y Medio Ambiente) Sabadell birth cohort, recruited between 2004 and 2006. Air pollution exposure was estimated for pregnancy, pre-school age, and school-age using temporally adjusted land use regression (LUR) modelling. Lung function was measured at ages 4, 7, 9 and 11 by spirometry. At age 4, serum CC16 levels were determined in 287 children. Multivariable linear regression models and linear mixed modelling were applied, while considering potential confounders. Prenatal exposure to Particulate Matter (PM) Increasing levels of air pollution exposure, particularly prenatal PM
Sections du résumé
BACKGROUND
Early life exposure to air pollution can affect lung health. Previous studies have not assessed the implications of both pre- and postnatal exposure to air pollutants on lung function at repeated ages during childhood. In addition, there is the need to identify potential mediators of such effect.
OBJECTIVES
To longitudinally assess the association between pre- and postnatal air pollution exposure and lung function during childhood. We also aimed to explore the role of Club cell secretory protein (CC16) as a potential mediator in this association.
METHODOLOGY
We included 487 mother-child pairs from the INMA (INfancia y Medio Ambiente) Sabadell birth cohort, recruited between 2004 and 2006. Air pollution exposure was estimated for pregnancy, pre-school age, and school-age using temporally adjusted land use regression (LUR) modelling. Lung function was measured at ages 4, 7, 9 and 11 by spirometry. At age 4, serum CC16 levels were determined in 287 children. Multivariable linear regression models and linear mixed modelling were applied, while considering potential confounders.
RESULTS
Prenatal exposure to Particulate Matter (PM)
CONCLUSION
Increasing levels of air pollution exposure, particularly prenatal PM
Identifiants
pubmed: 34419474
pii: S0013-9351(21)01195-6
doi: 10.1016/j.envres.2021.111900
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111900Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.