Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age.
Anisotropy
Brain
/ growth & development
Brain Cortical Thickness
Cerebral Cortex
/ growth & development
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
/ growth & development
Magnetic Resonance Imaging
/ methods
Male
Pregnancy
Pregnancy Trimester, Third
Premature Birth
/ diagnostic imaging
Cortical development
Heterogeneity
Neonatal neuroimaging
Preterm birth
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
04
06
2021
revised:
16
07
2021
accepted:
19
08
2021
pubmed:
23
8
2021
medline:
19
1
2022
entrez:
22
8
2021
Statut:
ppublish
Résumé
The dynamic nature and complexity of the cellular events that take place during the last trimester of pregnancy make the developing cortex particularly vulnerable to perturbations. Abrupt interruption to normal gestation can lead to significant deviations to many of these processes, resulting in atypical trajectory of cortical maturation in preterm birth survivors. We sought to first map typical cortical micro- and macrostructure development using invivo MRI in a large sample of healthy term-born infants scanned after birth (n = 259). Then we offer a comprehensive characterization of the cortical consequences of preterm birth in 76 preterm infants scanned at term-equivalent age (37-44 weeks postmenstrual age). We describe the group-average atypicality, the heterogeneity across individual preterm infants, and relate individual deviations from normative development to age at birth and neurodevelopment at 18 months. In the term-born neonatal brain, we observed heterogeneous and regionally specific associations between age at scan and measures of cortical morphology and microstructure, including rapid surface expansion, greater cortical thickness, lower cortical anisotropy and higher neurite orientation dispersion. By term-equivalent age, preterm infants had on average increased cortical tissue water content and reduced neurite density index in the posterior parts of the cortex, and greater cortical thickness anteriorly compared to term-born infants. While individual preterm infants were more likely to show extreme deviations (over 3.1 standard deviations) from normative cortical maturation compared to term-born infants, these extreme deviations were highly variable and showed very little spatial overlap between individuals. Measures of regional cortical development were associated with age at birth, but not with neurodevelopment at 18 months. We showed that preterm birth alters cortical micro- and macrostructural maturation near the time of full-term birth. Deviations from normative development were highly variable between individual preterm infants.
Identifiants
pubmed: 34419595
pii: S1053-8119(21)00761-8
doi: 10.1016/j.neuroimage.2021.118488
pmc: PMC8526870
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
118488Subventions
Organisme : Wellcome Trust
ID : WT 203,148/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006355/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206,675/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
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