Assessment of cellular response to mitogens in long-term allogeneic hematopoietic stem cell transplantation survivors.
Allogeneic HSCT
Long-term follow-up
Mitogen stimulation test
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
22
04
2021
accepted:
18
08
2021
revised:
17
08
2021
pubmed:
23
8
2021
medline:
17
12
2021
entrez:
22
8
2021
Statut:
ppublish
Résumé
Infection is one of the major causes of death in hematopoietic stem cell transplantation (HSCT) survivors. Precise assessments of immune function after HSCT will be critical in establishing appropriate treatment and prophylaxis, such as re-vaccination. Although several surrogate markers for prediction of clinical outcomes after HSCT have been proposed, definitive markers of immune reconstitution and data on those markers in long-term survivors are lacking. In this study, cellular response to mitogens was assessed and clinical features associated with a poor response to mitogens were investigated in long-term allogeneic HSCT survivors. Age at transplantation and age at the time of mitogen stimulation test were each identified as significant risk factors for poor response to phytohemagglutinin and concanavalin A, respectively (P < 0.001 each). However, time elapsed since transplantation was not found to be correlated with responsiveness to mitogens in this study. Prospective, in-depth studies on immune reconstitution are needed to establish appropriate prophylaxis against infections after HSCT and a schedule for re-vaccination.
Identifiants
pubmed: 34420193
doi: 10.1007/s12185-021-03206-7
pii: 10.1007/s12185-021-03206-7
doi:
Substances chimiques
Mitogens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
682-690Informations de copyright
© 2021. Japanese Society of Hematology.
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