A summary of surveillance, morbidity and microbiology of laboratory-confirmed cases of infant botulism in Canada, 1979-2019.
Canada
Clostridium baratii
Clostridium botulinum
Clostridium butyricum
botulinum neurotoxin
environmental source
geographic distribution
incidence rate
serotype
Journal
Canada communicable disease report = Releve des maladies transmissibles au Canada
ISSN: 1188-4169
Titre abrégé: Can Commun Dis Rep
Pays: Canada
ID NLM: 9303729
Informations de publication
Date de publication:
08 Jul 2021
08 Jul 2021
Historique:
entrez:
23
8
2021
pubmed:
24
8
2021
medline:
24
8
2021
Statut:
epublish
Résumé
Infant botulism is a rare toxicoinfectious disease caused by colonization of the infant's intestine with botulinum neurotoxin-producing clostridia (i.e. We examined laboratory records from the Health Canada Botulism Reference Service and the British Columbia Centre for Disease Control (BCCDC) Public Health Laboratory. The Discharge Abstract Database (DAD) and the Hospital Morbidity Database (HMDB) of the Canadian Institute of Health Information (CIHI) were queried for data on hospitalization of infant botulism cases. The CNDSS was queried for data on reported cases of infant botulism. From 1979 to 2019, 63 laboratory-confirmed cases of infant botulism were confirmed by the Health Canada Botulism Reference Service and the BCCDC Public Health Laboratory for an annual rate of 4.30 cases per million live births. From 1983 to 2018, 57 cases of infant botulism were reported to the CNDSS. Of the 63 cases confirmed by the reference laboratories, the median age of onset was 16 weeks with a range of 2 to 52 weeks. The majority of cases were type A (76%) and B (21%), with single cases of type F and type AB. Of the 23 laboratory-confirmed cases with matched hospital records, 13 were transferred to special care and eight needed ventilator support; no deaths were reported. Spores of
Sections du résumé
BACKGROUND
BACKGROUND
Infant botulism is a rare toxicoinfectious disease caused by colonization of the infant's intestine with botulinum neurotoxin-producing clostridia (i.e.
METHODS
METHODS
We examined laboratory records from the Health Canada Botulism Reference Service and the British Columbia Centre for Disease Control (BCCDC) Public Health Laboratory. The Discharge Abstract Database (DAD) and the Hospital Morbidity Database (HMDB) of the Canadian Institute of Health Information (CIHI) were queried for data on hospitalization of infant botulism cases. The CNDSS was queried for data on reported cases of infant botulism.
RESULTS
RESULTS
From 1979 to 2019, 63 laboratory-confirmed cases of infant botulism were confirmed by the Health Canada Botulism Reference Service and the BCCDC Public Health Laboratory for an annual rate of 4.30 cases per million live births. From 1983 to 2018, 57 cases of infant botulism were reported to the CNDSS. Of the 63 cases confirmed by the reference laboratories, the median age of onset was 16 weeks with a range of 2 to 52 weeks. The majority of cases were type A (76%) and B (21%), with single cases of type F and type AB. Of the 23 laboratory-confirmed cases with matched hospital records, 13 were transferred to special care and eight needed ventilator support; no deaths were reported.
CONCLUSION
CONCLUSIONS
Spores of
Identifiants
pubmed: 34421389
doi: 10.14745/ccdr.v47i78a05
pii: 477805
pmc: PMC8340675
doi:
Types de publication
Journal Article
Langues
eng
Pagination
322-328Déclaration de conflit d'intérêts
Competing interests None.
Références
J Pediatr. 2020 Dec;227:258-267.e8
pubmed: 32645406
Am J Dis Child. 1989 Jul;143(7):828-32
pubmed: 2741856
J Clin Microbiol. 1986 Jan;23(1):201-2
pubmed: 3517043
Eur J Clin Microbiol Infect Dis. 2002 Oct;21(10):736-8
pubmed: 12479171
J Pediatr. 1982 Apr;100(4):568-73
pubmed: 7038077
Clin Microbiol Rev. 1996 Apr;9(2):119-25
pubmed: 8964030
Paediatr Child Health. 2017 Mar;22(1):37-38
pubmed: 29479172
Pediatr Infect Dis J. 1995 Oct;14(10):912-4
pubmed: 8584326
Health Lab Sci. 1978 Apr;15(2):74-80
pubmed: 355208
Can Med Assoc J. 1978 Mar 4;118(5):484
pubmed: 343901
MMWR Morb Mortal Wkly Rep. 2015 Apr 17;64(14):400
pubmed: 25879901
CMAJ. 1986 Jul 15;135(2):130-1
pubmed: 3521822
J Clin Microbiol. 2005 Aug;43(8):4280-2
pubmed: 16082001
Pediatrics. 2008 Jul;122(1):e73-82
pubmed: 18595978
Appl Environ Microbiol. 2018 Aug 31;84(18):
pubmed: 30006390
Epidemiol Rev. 1981;3:45-66
pubmed: 7030764
N Engl J Med. 2006 Feb 2;354(5):462-71
pubmed: 16452558
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S11-S16
pubmed: 29293923
Botulinum J. 2015;3(1):6-17
pubmed: 28603554
Toxins (Basel). 2020 Jan 24;12(2):
pubmed: 31991691
J Pediatr. 2020 Dec;227:247-257.e3
pubmed: 32800814
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S92-S94
pubmed: 29293930
Annu Rev Med. 1980;31:541-60
pubmed: 6772092
J Infect Dis. 1986 Aug;154(2):207-11
pubmed: 3722863
CMAJ. 2012 Nov 20;184(17):1919-22
pubmed: 22988147
Can Med Assoc J. 1981 Oct 1;125(7):741-3
pubmed: 7326656
J Clin Microbiol. 2010 Jan;48(1):326-8
pubmed: 19906896
N Engl J Med. 1976 Sep 30;295(14):770-2
pubmed: 785257
J Clin Microbiol. 2005 Jan;43(1):511-3
pubmed: 15635031
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S73-S81
pubmed: 29293934
Lancet. 1976 Oct 30;2(7992):934-6
pubmed: 62164