Enalapril and Acute Kidney Injury in a Hypertensive Premature Newborn - Should It Be Used or Not?
acute kidney injury
enalapril
low birth weight
premature infants
Journal
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
ISSN: 1551-6776
Titre abrégé: J Pediatr Pharmacol Ther
Pays: United States
ID NLM: 101089851
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
11
2020
accepted:
28
12
2020
entrez:
23
8
2021
pubmed:
24
8
2021
medline:
24
8
2021
Statut:
ppublish
Résumé
Extremely low birth weight infants (birth weight ≤1000 g) have a significantly lower nephron number. The glomerular filtration rate (GFR) is usually sufficient under normal conditions but is unable to meet the needs during stress, which results in acute kidney injury (AKI). We describe the case of an extremely low birth weight infant (970 g) with a gestational age of 27 weeks (immature preterm) who was mechanically ventilated because of hyaline membrane disease. AKI with anuria and a rise in serum creatinine to 3.4 mg/dL developed in the second week. Diuresis was restored after diuretics and dopamine were administered intravenously and kidney function recovered in the next two weeks. However, he slowly became hypertensive, so intravenous enalapril was introduced in the 6
Identifiants
pubmed: 34421415
doi: 10.5863/1551-6776-26.6.638
pmc: PMC8372859
doi:
Types de publication
Journal Article
Langues
eng
Pagination
638-642Informations de copyright
Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email: mhelms@pediatricpharmacy.org 2021.
Déclaration de conflit d'intérêts
Disclosures. The authors declare no conflicts or financial interests in any product or service mentioned in the manuscript, including grants, equipment, medications, employement, gifts and honoraria.
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