A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes.
Alpha-glucosidase
Diabetes
IC50
Stilbenes
Tannins
Triterpenoids
Journal
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
ISSN: 1568-7767
Titre abrégé: Phytochem Rev
Pays: Netherlands
ID NLM: 101198162
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
10
2020
accepted:
27
07
2021
pubmed:
24
8
2021
medline:
24
8
2021
entrez:
23
8
2021
Statut:
ppublish
Résumé
Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. The online version contains supplementary material available at 10.1007/s11101-021-09773-1.
Identifiants
pubmed: 34421444
doi: 10.1007/s11101-021-09773-1
pii: 9773
pmc: PMC8364835
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1049-1079Informations de copyright
© The Author(s), under exclusive licence to Springer Nature B.V. 2021.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no conflicts of interest to declare that are relevant to the content of this article.
Références
Bioorg Med Chem Lett. 2014 Mar 1;24(5):1403-6
pubmed: 24507928
Antioxidants (Basel). 2019 Sep 20;8(10):
pubmed: 31547166
World J Gastroenterol. 2001 Feb;7(1):9-15
pubmed: 11819725
RSC Adv. 2019 Jun 3;9(30):17211-17219
pubmed: 35519885
Korean J Physiol Pharmacol. 2018 May;22(3):235-248
pubmed: 29719446
Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(14):2328-33
pubmed: 24199566
Mol Nutr Food Res. 2009 Jul;53(7):805-14
pubmed: 19496086
Lipids Health Dis. 2012 Aug 06;11:98
pubmed: 22867128
Curr Drug Metab. 2018;19(11):930-959
pubmed: 29788882
Fitoterapia. 2017 Jul;120:184-193
pubmed: 28647480
PLoS One. 2017 Aug 10;12(8):e0182464
pubmed: 28797051
Pharmacol Res. 2021 Jul;169:105615
pubmed: 33872808
Molecules. 2019 Nov 01;24(21):
pubmed: 31683764
Biopharm Drug Dispos. 2007 Mar;28(2):51-7
pubmed: 17163409
Lancet. 2014 Jan 4;383(9911):69-82
pubmed: 23890997
Oncotarget. 2017 Jul 14;8(34):57187-57200
pubmed: 28915664
J Agric Food Chem. 2016 Nov 23;64(46):8857-8865
pubmed: 27792335
Cardiovasc Endocrinol. 2017 Feb 15;6(1):8-16
pubmed: 31646113
BioData Min. 2015 Jun 28;8:19
pubmed: 26131021
Evid Based Complement Alternat Med. 2015;2015:513978
pubmed: 26246840
PLoS One. 2016 Sep 06;11(9):e0161704
pubmed: 27598258
Oxid Med Cell Longev. 2016;2016:3128951
pubmed: 26798416
Mol Pharm. 2013 Apr 1;10(4):1378-87
pubmed: 23339520
Biofactors. 2014 Nov-Dec;40(6):636-45
pubmed: 25422054
Drug Metab Dispos. 2016 Feb;44(2):162-71
pubmed: 26438626
Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1190-3
pubmed: 15467233
Mol Nutr Food Res. 2014 Oct;58(10):1970-9
pubmed: 25045029
Nat Prod Res. 2018 Jan;32(1):36-42
pubmed: 28521570
Expert Opin Pharmacother. 2019 Dec;20(18):2229-2235
pubmed: 31593486
J Funct Biomater. 2020 Sep 19;11(3):
pubmed: 32961705
J Nutr. 2012 May;142(5):853-8
pubmed: 22492122
Food Funct. 2020 Jan 29;11(1):66-82
pubmed: 31844870
Endocrine. 2002 Jul;18(2):105-19
pubmed: 12374457
Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G241-8
pubmed: 11804845
Food Funct. 2014 Sep;5(9):2357-64
pubmed: 25088664
Food Chem. 2014 Apr 1;148:24-9
pubmed: 24262521
Arch Pharm Res. 2004 Sep;27(9):947-53
pubmed: 15473666
Fitoterapia. 2004 Mar;75(2):228-30
pubmed: 15030932
Eur J Med Chem. 2015 Oct 20;103:133-62
pubmed: 26344912
Biomedicine (Taipei). 2015 Sep;5(3):13
pubmed: 26260291
Curr Diab Rep. 2016 Oct;16(10):102
pubmed: 27640169
Mol Cell Biol. 2000 Aug;20(15):5479-89
pubmed: 10891488
Int Immunopharmacol. 2018 May;58:117-124
pubmed: 29573719
J Biochem Mol Toxicol. 2021 Jan;35(1):e22631
pubmed: 32926752
Eur J Med Chem. 2018 Sep 5;157:1460-1479
pubmed: 30282319
Med Sci Monit. 2006 Jul;12(7):RA130-47
pubmed: 16810145
J Pharm Pharmacol. 2004 Oct;56(10):1315-21
pubmed: 15482647
J Ethnopharmacol. 2015 Apr 2;163:31-8
pubmed: 25596352
Toxicol Res. 2017 Oct;33(4):273-282
pubmed: 29071011
Pharmacognosy Res. 2015 Jul-Sep;7(3):225-36
pubmed: 26130933
Planta Med. 2009 Oct;75(13):1386-92
pubmed: 19877312
Front Mol Neurosci. 2019 May 29;12:143
pubmed: 31191248
Biomed Pharmacother. 2018 Jun;102:1015-1024
pubmed: 29710518
Clin Investig (Lond). 2013;3(4):333-341
pubmed: 26146540
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
J Ethnopharmacol. 2020 Feb 10;248:112296
pubmed: 31610262
Int J Mol Sci. 2018 Jul 20;19(7):
pubmed: 30036972
J Nat Prod. 2017 Apr 28;80(4):1087-1095
pubmed: 28240909
Diabetes Metab Syndr Obes. 2012;5:357-67
pubmed: 23093911
Pharmacol Rep. 2011;63(1):139-48
pubmed: 21441621
Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42
pubmed: 18485277
Biochem Pharmacol. 2011 Sep 1;82(5):524-34
pubmed: 21669192
Nat Prod Bioprospect. 2014 Feb;4(1):47-51
pubmed: 24660136
J Agric Food Chem. 2011 May 11;59(9):4589-96
pubmed: 21434689
AAPS PharmSciTech. 2009;10(1):172-82
pubmed: 19224372
Bioanalysis. 2012 Mar;4(6):713-23
pubmed: 22452262
J Clin Biochem Nutr. 2007 May;40(3):163-73
pubmed: 18398493
N Engl J Med. 2013 Dec 26;369(26):2492-503
pubmed: 24206459
Biomed Pharmacother. 2019 Mar;111:613-623
pubmed: 30611985
Nutr J. 2011 Mar 17;10:24
pubmed: 21414227
Toxicol Rep. 2017 Jun 04;4:274-281
pubmed: 28959649
Nutrients. 2019 Dec 22;12(1):
pubmed: 31877869
RSC Adv. 2018 Dec 5;8(70):40483-40489
pubmed: 35558232
Phytochem Rev. 2018 Feb;17(1):1-16
pubmed: 29651231
J Pharm Sci. 2010 Apr;99(4):2185-95
pubmed: 19921750
J Biol Chem. 2000 Feb 11;275(6):4283-9
pubmed: 10660596
Pharm Biol. 2016 Nov;54(11):2584-2590
pubmed: 27159241
J Ethnopharmacol. 2019 Apr 6;233:218-233
pubmed: 30686574
Int J Med Sci. 2014 Sep 06;11(11):1185-200
pubmed: 25249787
Nat Prod Res. 2016 Dec;30(23):2655-2661
pubmed: 26828875
Arch Pharm Res. 2008 May;31(5):598-605
pubmed: 18481015
Bioorg Chem. 2020 Jan;94:103400
pubmed: 31699390
Planta Med. 2019 Jan;85(2):112-117
pubmed: 30278472
Int J Pharm. 2002 Mar 20;235(1-2):179-92
pubmed: 11879753
Phytomedicine. 2019 Nov;64:153070
pubmed: 31514082
Phytochemistry. 2017 Nov;143:186-193
pubmed: 28825980
PLoS One. 2019 Aug 14;14(8):e0220379
pubmed: 31412050
Acc Chem Res. 2014 Jan 21;47(1):226-35
pubmed: 23957528
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 1;1029-1030:145-156
pubmed: 27428458
Antiviral Res. 2009 Apr;82(1):73-81
pubmed: 19428598
Food Funct. 2014 Feb;5(2):251-6
pubmed: 24362821
Bioorg Med Chem Lett. 2004 Jul 16;14(14):3841-5
pubmed: 15203173
Eur J Pharmacol. 2017 Apr 15;801:62-71
pubmed: 28283388
Phytomedicine. 2016 Nov 15;23(12):1451-1461
pubmed: 27765365
Clin Biochem Rev. 2005 May;26(2):19-39
pubmed: 16278749
Curr Comput Aided Drug Des. 2020;16(1):31-44
pubmed: 30345924
J Nutr. 2009 Aug;139(8):1469-73
pubmed: 19494022
Biol Pharm Bull. 2000 Jul;23(7):830-3
pubmed: 10919361
Oncol Lett. 2016 Jan;11(1):267-272
pubmed: 26870201
J Appl Toxicol. 2011 Nov;31(8):790-800
pubmed: 21319176
Molecules. 2018 Aug 28;23(9):
pubmed: 30154376
J Pharm Biomed Anal. 2014 Jan;88:483-8
pubmed: 24176754
Reprod Toxicol. 2015 Jan;51:14-21
pubmed: 25463531
ACS Omega. 2019 Sep 18;4(14):16139-16152
pubmed: 31592482
Protein Sci. 2018 Aug;27(8):1498-1508
pubmed: 29761590
Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):148-70
pubmed: 22559241
Biomolecules. 2020 Jan 29;10(2):
pubmed: 32013271
Phytother Res. 2020 Mar;34(3):486-504
pubmed: 31773816
Malar J. 2011 Mar 15;10 Suppl 1:S4
pubmed: 21411015
J Nat Prod. 2008 Dec;71(12):2068-72
pubmed: 19061390
Cardiovasc Diabetol. 2018 Aug 31;17(1):122
pubmed: 30170598
J Pharm Biomed Anal. 2012 Dec;71:71-8
pubmed: 22944356
World J Diabetes. 2015 Apr 15;6(3):380-90
pubmed: 25897349
RSC Adv. 2018 Sep 21;8(57):32621-32636
pubmed: 35547672
J Pharm Biomed Anal. 2018 May 30;154:339-353
pubmed: 29571132
J Ethnopharmacol. 2016 Sep 15;191:152-160
pubmed: 27321278
BMC Complement Altern Med. 2018 Oct 1;18(1):267
pubmed: 30285723
Phytochemistry. 2017 May;137:109-116
pubmed: 28213992
Plants (Basel). 2017 Sep 22;6(4):
pubmed: 28937585
Int J Biol Macromol. 2017 Feb;95:757-761
pubmed: 27939269
Luminescence. 2013 Jul-Aug;28(4):523-9
pubmed: 23364836
Biomed Chromatogr. 2014 Apr;28(4):564-72
pubmed: 24136708
Diabetes Res Clin Pract. 2007 Jul;77(1):41-6
pubmed: 17098323
Phytomedicine. 2016 Aug 15;23(9):939-47
pubmed: 27387402
Toxicol In Vitro. 2015 Feb;29(1):228-33
pubmed: 25448808
Am J Cancer Res. 2014 Dec 15;5(1):289-99
pubmed: 25628938
Int J Pharm. 2016 Aug 20;510(1):203-9
pubmed: 27154253
Molecules. 2014 Apr 04;19(4):4301-12
pubmed: 24714192
Phytochemistry. 2019 Jan;157:82-91
pubmed: 30390605
Drug Des Devel Ther. 2012;6:371-84
pubmed: 23251087
Curr Drug Metab. 2015;16(6):453-73
pubmed: 26264203
J Diabetes Investig. 2017 Nov;8(6):723-725
pubmed: 28752566
Chin J Integr Med. 2019 Oct;25(10):757-762
pubmed: 27025925
Life Sci. 2003 Jul 4;73(7):857-69
pubmed: 12798412
Planta Med. 2009 Apr;75(5):472-7
pubmed: 19235684
J Agric Food Chem. 2010 Nov 24;58(22):11667-72
pubmed: 20964424
Brain Res Bull. 2006 Dec 11;71(1-3):29-36
pubmed: 17113925
Xenobiotica. 2016;46(5):467-76
pubmed: 26372370
Postgrad Med J. 2015 Nov;91(1081):612-21
pubmed: 26453594
Anticancer Agents Med Chem. 2014;14(10):1351-62
pubmed: 25019627
J Ethnopharmacol. 2011 Nov 18;138(2):314-32
pubmed: 22004895
Fitoterapia. 2017 Mar;117:65-70
pubmed: 27889542
Clin Invest Med. 1995 Aug;18(4):303-11
pubmed: 8549017
Bioorg Med Chem. 2013 Jan 1;21(1):178-85
pubmed: 23177726
Br J Nutr. 2010 Apr;103(7):944-52
pubmed: 20003617
Foods. 2019 May 30;8(6):
pubmed: 31151279
Chem Biodivers. 2021 May;18(5):e2001030
pubmed: 33779055
Molecules. 2016 Dec 27;22(1):
pubmed: 28035984
Arch Pharm Res. 2014 Nov;37(11):1403-10
pubmed: 24297667
Food Chem Toxicol. 2010 Jun;48(6):1528-36
pubmed: 20304026
PLoS One. 2020 Aug 5;15(8):e0237017
pubmed: 32756588
Oncol Rep. 2007 Aug;18(2):347-51
pubmed: 17611655
Nucleic Acids Res. 2014 Jan;42(Database issue):D490-5
pubmed: 24270786
J Biochem Mol Toxicol. 2020 Nov;34(11):e22568
pubmed: 32662907
Phytochemistry. 2018 Nov;155:114-125
pubmed: 30103164
Int J Mol Sci. 2018 May 22;19(5):
pubmed: 29786669