Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Alzheimer's disease
Biomarkers
Down syndrome
Intellectual disability
Language impairment
Mouse models
Neurodevelopmental disorders
Trisomy 21 Research Society
Journal
Molecular syndromology
ISSN: 1661-8769
Titre abrégé: Mol Syndromol
Pays: Switzerland
ID NLM: 101525192
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
05
10
2020
accepted:
13
01
2021
entrez:
23
8
2021
pubmed:
24
8
2021
medline:
24
8
2021
Statut:
ppublish
Résumé
Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. The Third International Conference of T21RS, held June 6-9, 2019, in Barcelona, Spain, brought together 429 scientists, families, and industry representatives to share the latest discoveries on underlying cellular and molecular mechanisms of T21, define cognitive and behavioral challenges and better understand comorbidities associated with Down syndrome, including Alzheimer's disease and leukemia. Presentation of cutting-edge results in neuroscience, neurology, model systems, psychology, cancer, biomarkers and molecular and phar-ma-cological therapeutic approaches demonstrate the compelling interest and continuing advancement in all aspects of understanding and ameliorating conditions associated with T21.
Identifiants
pubmed: 34421499
doi: 10.1159/000514437
pii: msy-0012-0202
pmc: PMC8339505
doi:
Types de publication
Journal Article
Langues
eng
Pagination
202-218Subventions
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/S001298/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Informations de copyright
Copyright © 2021 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Nat Rev Neurosci. 2015 Sep;16(9):564-74
pubmed: 26243569
Circ Res. 2018 Mar 16;122(6):e20-e33
pubmed: 29362227
Nature. 2016 Dec 7;540(7632):230-235
pubmed: 27929004
Mol Syndromol. 2019 Jan;9(6):279-286
pubmed: 30800043
Neurobiol Dis. 2020 Feb;134:104616
pubmed: 31678403
Front Neurosci. 2020 Jul 08;14:670
pubmed: 32733190
Alzheimers Dement (N Y). 2018 Dec 13;4:703-713
pubmed: 30581976
Am J Intellect Dev Disabil. 2019 Jan;124(1):4-10
pubmed: 30715921
Dev Neurobiol. 2019 Jul;79(7):639-655
pubmed: 31347291
Nat Commun. 2019 Oct 18;10(1):4766
pubmed: 31628327
Neurobiol Dis. 2020 Apr;137:104772
pubmed: 31987911
Cell Stem Cell. 2019 Apr 4;24(4):535-550.e9
pubmed: 30905618
Cell. 2019 Apr 4;177(2):256-271.e22
pubmed: 30879788
Dev Disabil Res Rev. 2013;18(1):31-42
pubmed: 23949827
Nature. 2013 Aug 15;500(7462):296-300
pubmed: 23863942
Alzheimers Dement. 2019 Feb;15(2):245-257
pubmed: 30503169
Cell Rep. 2019 Nov 19;29(8):2473-2488.e5
pubmed: 31747614
Dis Model Mech. 2020 Sep 25;13(9):
pubmed: 32817053
PLoS One. 2019 Jul 29;14(7):e0219592
pubmed: 31356639
Aging Ment Health. 2018 Nov;22(11):1406-1415
pubmed: 28880125
Clin Cancer Res. 2020 Jul 1;26(13):3307-3318
pubmed: 32220889
Alzheimers Dement. 2017 May;13(5):541-549
pubmed: 27755974
Neurobiol Dis. 2017 Oct;106:76-88
pubmed: 28647555
Mol Psychiatry. 2020 Jul 10;:
pubmed: 32647257
Science. 2018 Nov 16;362(6416):
pubmed: 30309905
Lancet. 2020 Jun 27;395(10242):1988-1997
pubmed: 32593336
J Intellect Disabil Res. 2018 Jul;62(7):617-624
pubmed: 29781149
Dis Model Mech. 2018 Jun 12;11(6):
pubmed: 29716957
Brain Behav Immun. 2018 Oct;73:235-251
pubmed: 29758264
Stem Cell Reports. 2018 Jul 10;11(1):32-42
pubmed: 29861166
Ann Clin Transl Neurol. 2018 May 20;5(6):741-751
pubmed: 29928657
Sci Transl Med. 2019 May 22;11(493):
pubmed: 31118292
J Clin Sleep Med. 2018 Oct 15;14(10):1725-1733
pubmed: 30353801
Elife. 2020 Jun 29;9:
pubmed: 32597754
Nat Commun. 2019 Oct 3;10(1):4495
pubmed: 31582743
Dev Cell. 2018 Sep 10;46(5):641-650.e6
pubmed: 30100262
Acta Neuropathol. 2018 Oct;136(4):569-587
pubmed: 29770843
Nat Commun. 2018 Jan 18;9(1):291
pubmed: 29348617
Hum Mol Genet. 2020 Mar 27;29(5):785-802
pubmed: 31943018
Sci Rep. 2020 Jun 26;10(1):10491
pubmed: 32591596
Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3):
pubmed: 30936119
Am J Intellect Dev Disabil. 2017 May;122(3):247-281
pubmed: 28452584
Brain. 2018 Aug 1;141(8):2457-2474
pubmed: 29945247
Alzheimers Res Ther. 2018 Apr 10;10(1):39
pubmed: 29631614
J Alzheimers Dis. 2018;61(2):717-728
pubmed: 29226868
Dev Cell. 2020 Feb 10;52(3):294-308.e3
pubmed: 31978324
Cell Rep. 2018 Jun 5;23(10):2967-2975
pubmed: 29874583
Mol Syndromol. 2016 Oct;7(5):251-261
pubmed: 27867340