Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy.

association study gene expression hippocampal atrophy mesial temporal sclerosis neuroinflammation

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2021
Historique:
received: 04 04 2021
accepted: 28 06 2021
entrez: 23 8 2021
pubmed: 24 8 2021
medline: 24 8 2021
Statut: epublish

Résumé

We aimed to investigate the role of interleukin-1 beta (IL-1β) in the mechanisms underlying mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). We assessed a cohort of 194 patients with MTLE+HS and 199 healthy controls. Patients were divided into those with positive and negative antecedent febrile seizures (FS). We used a multidimensional approach, including (i) genetic association with single nucleotide polymorphisms (SNPs) in the

Identifiants

pubmed: 34421794
doi: 10.3389/fneur.2021.690847
pmc: PMC8375265
doi:

Types de publication

Journal Article

Langues

eng

Pagination

690847

Informations de copyright

Copyright © 2021 Santos, Secolin, Barbalho, Silva-Alves, Alvim, Yasuda, Rogerio, Velasco, Sakamoto, Teixeira, Cendes, Maurer-Morelli and Lopes-Cendes.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The Handling Editor KV declared a shared affiliation, though no other collaboration, with one or more authors TV and AS at the time of the review.

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Auteurs

Renato O Santos (RO)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Rodrigo Secolin (R)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Patrícia G Barbalho (PG)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Mariana S Silva-Alves (MS)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Marina K M Alvim (MKM)

Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Department of Neurology, University of Campinas, Campinas, Brazil.

Clarissa L Yasuda (CL)

Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Department of Neurology, University of Campinas, Campinas, Brazil.

Fábio Rogerio (F)

Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Department of Pathology, University of Campinas, Campinas, Brazil.

Tonicarlo R Velasco (TR)

Department of Neuroscience and Behavioral Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Americo C Sakamoto (AC)

Department of Neuroscience and Behavioral Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Antonio L Teixeira (AL)

Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Fernando Cendes (F)

Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Department of Neurology, University of Campinas, Campinas, Brazil.

Claudia V Maurer-Morelli (CV)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Iscia Lopes-Cendes (I)

Department of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.

Classifications MeSH