Human papillomavirus-related multiphenotypic sinonasal carcinoma: a clinico-pathological dilemma case report.
Human papillomavirus
carcinoma
case report
immunohistochemistry
sinonasal tract
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
09
2020
accepted:
22
09
2020
entrez:
23
8
2021
pubmed:
24
8
2021
medline:
3
9
2021
Statut:
epublish
Résumé
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), is a new entity that is restricted to the sinonasal tract and is associated with high-risk HPV. This tumor is suggested to have an indolent behavior with a better prognosis than other carcinomas. We report a unique case of HMSC with a locally aggressive behavior. It is about a 61-year-old men presented with 12 months of unilateral progressive olfactory dysfunction accompanied by exophthalmia of the left eye, declining vision and headaches for 6 months. Computed tomography imaging revealed a voluminous mass occupying the ethmoid, maxillary and frontal sinus with bony destruction of the left ethmoidal blade. Histology showed a tumor composed of variably sized nests, separated by thick mucoid stroma. Tumor cells are plasmacytoid with hyperchromatic nuclei and frequent mitoses. Immunohistochemistry revealed that these cells were positive for cytokeratin AE1/AE3, p16 and negative for CK7, CK20, CD117, p40, p63, S100, synaptophysin and chromogranin.
Identifiants
pubmed: 34422201
doi: 10.11604/pamj.2021.39.78.26043
pii: PAMJ-39-78
pmc: PMC8363977
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
78Informations de copyright
Copyright: Nouha Ben Abdeljelil et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Hum Pathol. 2018 Dec;82:264-272
pubmed: 30071233
Cancer Discov. 2016 Feb;6(2):176-87
pubmed: 26631070
Clin Cancer Res. 2016 Feb 1;22(3):725-33
pubmed: 26631609
Am J Surg Pathol. 2013 Jun;37(6):836-44
pubmed: 23598962
Head Neck Pathol. 2019 Dec;13(4):543-547
pubmed: 30498968
Oral Oncol. 2018 Dec;87:17-20
pubmed: 30527234
Head Neck Pathol. 2018 Dec;12(4):623-628
pubmed: 29445997
J Neurol Surg Rep. 2019 Oct;80(4):e41-e43
pubmed: 31737465
Am J Surg Pathol. 2017 Dec;41(12):1690-1701
pubmed: 28877065
Laryngoscope. 2021 Jan;131(1):106-110
pubmed: 32159863
Arch Pathol Lab Med. 2019 Nov;143(11):1420-1424
pubmed: 30838880
Head Neck Pathol. 2020 Jun;14(2):473-479
pubmed: 31473938
Int J Surg Pathol. 2019 Dec;27(8):888-892
pubmed: 31405309
Histopathology. 2017 May;70(6):880-888
pubmed: 28035703
Head Neck Pathol. 2019 Sep;13(3):331-338
pubmed: 30259271
Head Neck Pathol. 2019 Jun;13(2):220-224
pubmed: 30027386