IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma.
BCL3
IL6
biomarker
diagnosis
esophageal squamous cell carcinoma (ESCC)
therapeutic target
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
06
2021
accepted:
22
07
2021
entrez:
23
8
2021
pubmed:
24
8
2021
medline:
24
8
2021
Statut:
epublish
Résumé
Esophageal squamous cell carcinoma (ESCC) ranks among the most lethal tumors worldwide, as a consequence of late detection and poor treatment response, evidencing the need for diagnosis anticipation and new therapeutic targets. First, we investigated the IL6 gene and protein expression in the esophagus of individuals without esophageal disorders (healthy), ESCC, and non-tumoral surrounding tissue (NTST). Our results showed that IL6 mRNA and protein expression is upregulated in tumor cells relative to NTST. In the TCGA dataset, we identified a set of genes whose expression was correlated with
Identifiants
pubmed: 34422669
doi: 10.3389/fonc.2021.722417
pmc: PMC8371528
doi:
Types de publication
Journal Article
Langues
eng
Pagination
722417Informations de copyright
Copyright © 2021 Soares-Lima, Gonzaga, Camuzi, Nicolau-Neto, Vieira da Silva, Guaraldi, Ferreira, Hernandez-Vargas, Herceg and Ribeiro Pinto.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Res. 2021 May 15;81(10):2612-2624
pubmed: 33741694
J Pathol. 2013 Nov;231(3):311-22
pubmed: 23868181
Leuk Lymphoma. 2002 Apr;43(4):813-6
pubmed: 12153169
Nature. 1992 Sep 24;359(6393):339-42
pubmed: 1406939
Mol Cancer. 2011 Dec 23;10:152
pubmed: 22195643
Epigenetics. 2011 Oct 1;6(10):1217-27
pubmed: 21946330
Br J Cancer. 2003 Aug 18;89(4):605-11
pubmed: 12915864
Dis Markers. 2013;35(6):883-93
pubmed: 24427776
Oncogene. 2000 Feb 24;19(9):1123-31
pubmed: 10713699
Int J Clin Exp Med. 2015 Jul 15;8(7):10340-57
pubmed: 26379825
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5490-4
pubmed: 2410927
Clin Epigenetics. 2017 Dec 20;9:130
pubmed: 29296124
J Biol Chem. 2018 Oct 5;293(40):15483-15496
pubmed: 30135206
Cold Spring Harb Perspect Biol. 2014 Sep 04;6(10):a016295
pubmed: 25190079
Dis Esophagus. 2012 Apr;25(3):242-9
pubmed: 21895853
Blood. 2012 Apr 19;119(16):3864-6
pubmed: 22517878
J Surg Oncol. 2011 Jan 1;103(1):62-8
pubmed: 21031427
Cancer Prev Res (Phila). 2011 Dec;4(12):1982-92
pubmed: 21952583
Cancer Res. 2018 Sep 1;78(17):4957-4970
pubmed: 29976575
BMB Rep. 2018 Feb;51(2):92-97
pubmed: 29335071
Cancer Res. 2003 Dec 1;63(23):8293-301
pubmed: 14678988
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
J Dig Dis. 2017 Aug;18(8):431-444
pubmed: 28749599
Sci Transl Med. 2018 Jul 4;10(448):
pubmed: 29973405
Cancer. 1953 Sep;6(5):963-8
pubmed: 13094644
Oncogene. 2006 Nov 23;25(55):7297-304
pubmed: 16732314
Clin Cancer Res. 2015 Mar 1;21(5):950-4
pubmed: 25601959
Exp Mol Pathol. 2016 Apr;100(2):325-31
pubmed: 26899552
Ann Surg Oncol. 2018 Aug;25(8):2449-2456
pubmed: 29948421
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Tumour Biol. 2016 Sep;37(9):11553-11572
pubmed: 27260630
Dis Model Mech. 2019 Mar 4;12(3):
pubmed: 30792270
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
N Engl J Med. 2014 Dec 25;371(26):2499-509
pubmed: 25539106
J Med Internet Res. 2021 Jul 26;23(7):e27633
pubmed: 34309564
Oncogene. 2003 Oct 30;22(49):7809-18
pubmed: 14586407
Br J Cancer. 1999 Jul;80(10):1617-22
pubmed: 10408408