Low Rates of Radiographic Knee Osteoarthritis 5 Years After ACL Reconstruction or Rehabilitation Alone: The Delaware-Oslo ACL Cohort Study.

ACL aging athlete knee; articular cartilage physical therapy/rehabilitation

Journal

Orthopaedic journal of sports medicine
ISSN: 2325-9671
Titre abrégé: Orthop J Sports Med
Pays: United States
ID NLM: 101620522

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 09 02 2021
accepted: 28 02 2021
entrez: 23 8 2021
pubmed: 24 8 2021
medline: 24 8 2021
Statut: epublish

Résumé

Patients and clinicians often struggle to choose the optimal management strategy for posttraumatic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. An evaluation of radiographic outcomes after a decision-making and treatment algorithm applicable in clinical practice can help to inform future recommendations and treatment choices. To describe and compare 5-year radiographic outcomes and knee pain in individuals who had gone through our decision-making and treatment algorithm and chosen (1) early (<6 months) ACL reconstruction (ACLR) with pre- and postoperative rehabilitation, (2) delayed (>6 months) ACLR with pre- and postoperative rehabilitation, or (3) progressive rehabilitation alone. Cohort study; Level of evidence, 2. We included 276 patients with unilateral ACL injury from a prospective cohort study. Patients chose management using a shared decision-making process and treatment algorithm, and 5-year postoperative radiographs of the index and contralateral knees were assessed using the Kellgren and Lawrence (K&L) classification and minimum joint space width measurements. We defined radiographic tibiofemoral OA as K&L grade ≥2 and knee pain as a Knee injury and Osteoarthritis Outcome Score for Pain ≤72. To further explore early radiographic changes, we included alternative cutoffs for radiographic knee OA using K&L grade ≥2/osteophyte (definite osteophyte without joint space narrowing) and K&L grade ≥1. At 5 years, 64% had undergone early ACLR; 11%, delayed ACLR; and 25%, progressive rehabilitation alone. Radiographic examination was attended by 187 patients (68%). Six percent of the cohort had radiographic tibiofemoral OA (K&L grade ≥2) in the index knee; 4%, in the contralateral knee. Using the alternative cutoffs at K&L grade ≥2/osteophyte and K&L grade ≥1, the corresponding numbers were 20% and 33% in the index knee and 18% and 29% in the contralateral knee. Six percent had a painful index knee. There were no statistically significant differences in any radiographic outcomes or knee pain among the 3 management groups. There were no statistically significant differences in any 5-year radiographic outcomes or knee pain among the 3 management groups. Very few of the patients who participated in our decision-making and treatment algorithm had knee OA or knee pain at 5 years.

Sections du résumé

BACKGROUND BACKGROUND
Patients and clinicians often struggle to choose the optimal management strategy for posttraumatic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. An evaluation of radiographic outcomes after a decision-making and treatment algorithm applicable in clinical practice can help to inform future recommendations and treatment choices.
PURPOSE OBJECTIVE
To describe and compare 5-year radiographic outcomes and knee pain in individuals who had gone through our decision-making and treatment algorithm and chosen (1) early (<6 months) ACL reconstruction (ACLR) with pre- and postoperative rehabilitation, (2) delayed (>6 months) ACLR with pre- and postoperative rehabilitation, or (3) progressive rehabilitation alone.
STUDY DESIGN METHODS
Cohort study; Level of evidence, 2.
METHODS METHODS
We included 276 patients with unilateral ACL injury from a prospective cohort study. Patients chose management using a shared decision-making process and treatment algorithm, and 5-year postoperative radiographs of the index and contralateral knees were assessed using the Kellgren and Lawrence (K&L) classification and minimum joint space width measurements. We defined radiographic tibiofemoral OA as K&L grade ≥2 and knee pain as a Knee injury and Osteoarthritis Outcome Score for Pain ≤72. To further explore early radiographic changes, we included alternative cutoffs for radiographic knee OA using K&L grade ≥2/osteophyte (definite osteophyte without joint space narrowing) and K&L grade ≥1.
RESULTS RESULTS
At 5 years, 64% had undergone early ACLR; 11%, delayed ACLR; and 25%, progressive rehabilitation alone. Radiographic examination was attended by 187 patients (68%). Six percent of the cohort had radiographic tibiofemoral OA (K&L grade ≥2) in the index knee; 4%, in the contralateral knee. Using the alternative cutoffs at K&L grade ≥2/osteophyte and K&L grade ≥1, the corresponding numbers were 20% and 33% in the index knee and 18% and 29% in the contralateral knee. Six percent had a painful index knee. There were no statistically significant differences in any radiographic outcomes or knee pain among the 3 management groups.
CONCLUSION CONCLUSIONS
There were no statistically significant differences in any 5-year radiographic outcomes or knee pain among the 3 management groups. Very few of the patients who participated in our decision-making and treatment algorithm had knee OA or knee pain at 5 years.

Identifiants

pubmed: 34423060
doi: 10.1177/23259671211027530
pii: 10.1177_23259671211027530
pmc: PMC8375355
doi:

Types de publication

Journal Article

Langues

eng

Pagination

23259671211027530

Subventions

Organisme : NICHD NIH HHS
ID : R37 HD037985
Pays : United States

Informations de copyright

© The Author(s) 2021.

Déclaration de conflit d'intérêts

One or more of the authors has declared the following potential conflict of interest or source of funding: This study was funded by the National Institutes of Health (grant R37HD37985). AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

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Auteurs

Marie Pedersen (M)

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.

Hege Grindem (H)

Oslo Sport Trauma Research Center, Norwegian School of Sport Sciences, Oslo, Norway.
Stockholm Sports Trauma Research Center, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Bjørnar Berg (B)

Orthopedic Clinic, Oslo University Hospital, Oslo, Norway.
Faculty of Medicine, Department of Interdisciplinary Health Sciences, University of Oslo, Oslo, Norway.

Ragnhild Gunderson (R)

Department of Radiology, Oslo University Hospital, Oslo, Norway.

Lars Engebretsen (L)

Oslo Sport Trauma Research Center, Norwegian School of Sport Sciences, Oslo, Norway.
Orthopedic Clinic, Oslo University Hospital, Oslo, Norway.

Michael J Axe (MJ)

Department of Physical Therapy, University of Delaware, Newark, Delaware, USA.
First State Orthopaedics, Newark, Delaware, USA.

Lynn Snyder-Mackler (L)

Department of Physical Therapy, University of Delaware, Newark, Delaware, USA.
Graduate Program in Biomechanics and Movement Science, University of Delaware, Newark, Delaware, USA.

May Arna Risberg (MA)

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Orthopedic Clinic, Oslo University Hospital, Oslo, Norway.

Classifications MeSH