Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity-Related Osteoarthritis.
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
19
07
2021
received:
22
12
2020
accepted:
19
08
2021
pubmed:
24
8
2021
medline:
19
2
2022
entrez:
23
8
2021
Statut:
ppublish
Résumé
To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in obesity-associated osteoarthritis (OA). Stool and blood samples were collected from 92 participants with a body mass index (BMI) ≥30 kg/m On average, OA patients were slightly older than the controls, consisted of more women, and had a higher mean BMI, higher mean Western Ontario and McMaster Universities Osteoarthritis Index pain score, and higher mean K/L grade. There were no significant differences in α- or β-diversity or genus level composition between patients and controls. Patients had higher plasma levels of osteopontin (P = 0.01) and serum LPS (P < 0.0001) compared to controls. Mice transplanted with patient or control microbiota exhibited a significant difference in α-diversity (P = 0.02) and β-diversity, but no differences in OA severity were observed. The lack of differences in the gut microbiota, but increased serum LPS levels, suggest the possibility that increased intestinal permeability allowing for greater absorption of LPS, rather than a dysbiotic microbiota, may contribute to the development of OA associated with obesity.
Identifiants
pubmed: 34423918
doi: 10.1002/art.41955
pmc: PMC8795472
mid: NIHMS1735156
doi:
Substances chimiques
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-236Subventions
Organisme : NIDDK NIH HHS
ID : P30-DK-056350
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30-DK-034987
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30-AR-072580
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002489
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR-002489
Pays : United States
Organisme : Arthritis Foundation
Organisme : Office of the Director, NIH
ID : P40-OD-010995
Organisme : NIAMS NIH HHS
ID : P30 AR072580
Pays : United States
Organisme : NIH HHS
ID : P40 OD010995
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP006266
Pays : United States
Organisme : CDC HHS
ID : U01-DP-006266
Pays : United States
Organisme : Nutrition Obesity Resource Core of the National Institute of Diabetes and Digestive and Kidney Diseases
ID : P30-DK-056350
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Informations de copyright
© 2021, American College of Rheumatology.
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