Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.
data-driven
functional MRI
functional connectivity
resting-state
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
04 03 2022
04 03 2022
Historique:
received:
29
04
2021
revised:
19
07
2021
accepted:
20
07
2021
pubmed:
24
8
2021
medline:
23
4
2022
entrez:
23
8
2021
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is characterized by atypical connectivity lateralization of functional networks. However, previous studies have not directly investigated if differences in specialization between ASD and typically developing (TD) peers are present in infancy, leaving the timing of onset of these differences relatively unknown. We studied the hemispheric asymmetries of connectivity in children with ASD and infants later meeting the diagnostic criteria for ASD. Analyses were performed in 733 children with ASD and TD peers and in 71 infants at high risk (HR) or normal risk (NR) for ASD, with data collected at 1 month and 9 months of age. Comparing children with ASD (n = 301) to TDs (n = 432), four regions demonstrated group differences in connectivity: posterior cingulate cortex (PCC), posterior superior temporal gyrus, extrastriate cortex, and anterior prefrontal cortex. At 1 month, none of these regions exhibited group differences between ASD (n = 10), HR-nonASD (n = 15), or NR (n = 18) infants. However, by 9 months, the PCC and extrastriate exhibited atypical connectivity in ASD (n = 11) and HR-nonASD infants (n = 24) compared to NR infants (n = 22). Connectivity did not correlate with symptoms in either sample. Our results demonstrate that differences in network asymmetries associated with ASD risk are observable prior to the age of a reliable clinical diagnosis.
Identifiants
pubmed: 34424949
pii: 6356432
doi: 10.1093/cercor/bhab284
pmc: PMC8924430
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1212-1222Subventions
Organisme : NIMH NIH HHS
ID : R03 MH096321
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH115716
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH087770
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH107045
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Références
Pediatrics. 2011 Sep;128(3):e488-95
pubmed: 21844053
Neurology. 2014 Dec 9;83(24):2269-77
pubmed: 25391304
J Neurodev Disord. 2017 Jul 19;9(1):27
pubmed: 28728548
Brain Res. 2008 Jul 24;1221:115-25
pubmed: 18555209
J Autism Dev Disord. 2009 Sep;39(9):1305-20
pubmed: 19415479
JAMA Psychiatry. 2013 Sep;70(9):975-82
pubmed: 23903586
Cereb Cortex. 2015 Jul;25(7):1858-66
pubmed: 24451659
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13507-12
pubmed: 17679691
Brain. 2015 Jul;138(Pt 7):2046-58
pubmed: 25937563
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
pubmed: 12506194
J Neurosci. 2014 Sep 10;34(37):12341-52
pubmed: 25209275
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Aug;6(8):802-812
pubmed: 33097470
Cereb Cortex. 2009 Feb;19(2):414-23
pubmed: 18562332
Neuroinformatics. 2011 Mar;9(1):69-84
pubmed: 21249532
Cereb Cortex. 2017 Mar 1;27(3):1709-1720
pubmed: 28062515
Prog Brain Res. 2016;225:213-42
pubmed: 27130418
Biol Psychiatry. 2017 Aug 1;82(3):176-185
pubmed: 28460842
Arch Gen Psychiatry. 2012 Mar;69(3):306-13
pubmed: 22065253
Biol Psychiatry. 2008 Oct 1;64(7):589-98
pubmed: 18672231
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Brain Struct Funct. 2016 Jul;221(6):3211-22
pubmed: 26341628
Sci Data. 2017 Mar 14;4:170010
pubmed: 28291247
Neuroimage. 2014 Jul 15;95:13-21
pubmed: 24657356
Cereb Cortex. 2019 Feb 1;29(2):573-585
pubmed: 29300843
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6790-5
pubmed: 19351894
Elife. 2017 Sep 12;6:
pubmed: 28893378
Cell. 2013 Nov 21;155(5):997-1007
pubmed: 24267886
Mol Autism. 2015 Dec 30;6:69
pubmed: 26719787
Cereb Cortex. 2017 Jan 1;27(1):534-543
pubmed: 26494796
Trends Cogn Sci. 2018 May;22(5):452-469
pubmed: 29609895
Infant Behav Dev. 2016 Aug;44:59-67
pubmed: 27314943
Cereb Cortex. 2012 Jan;22(1):13-25
pubmed: 21571694
Sci Transl Med. 2017 Jun 7;9(393):
pubmed: 28592562
Front Psychol. 2013 Sep 26;4:664
pubmed: 24133469
Nat Neurosci. 2018 May;21(5):765-772
pubmed: 29632361
J Child Psychol Psychiatry. 2015 Sep;56(9):988-98
pubmed: 25921776
Mol Psychiatry. 2014 Jun;19(6):659-67
pubmed: 23774715
Harv Rev Psychiatry. 2015 Jul-Aug;23(4):223-44
pubmed: 26146755
Nature. 2013 Dec 19;504(7480):427-31
pubmed: 24196715
Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52
pubmed: 15749241
Front Neurosci. 2016 May 03;10:191
pubmed: 27199653
Cereb Cortex. 2011 May;21(5):1134-46
pubmed: 20943668
Schizophr Bull. 2019 Mar 7;45(2):415-424
pubmed: 29660081
Mol Autism. 2014 Feb 06;5(1):8
pubmed: 24502324
MMWR Surveill Summ. 2020 Mar 27;69(4):1-12
pubmed: 32214087
Biol Psychiatry. 2017 Aug 1;82(3):186-193
pubmed: 28392081
Child Neuropsychol. 2020 Feb;26(2):170-188
pubmed: 31385559
Magn Reson Imaging. 2001 Jan;19(1):1-5
pubmed: 11295339
Brain. 2012 Sep;135(Pt 9):2711-25
pubmed: 22791801
Neuroimage. 2013 Jan 1;64:240-56
pubmed: 22926292
Infant Behav Dev. 2012 Dec;35(4):838-46
pubmed: 22982285
Mol Autism. 2016 Jul 14;7:35
pubmed: 27429731
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Sep;2(6):476-486
pubmed: 29034353