TRIM21 negatively regulates Corynebacterium pseudotuberculosis-induced inflammation and is critical for the survival of C. pseudotuberculosis infected C57BL6 mice.
Corynebacterium pseudotuberculosis
Inflammation
Macrophages
TRIM21
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
06
04
2021
accepted:
13
08
2021
pubmed:
24
8
2021
medline:
5
11
2021
entrez:
23
8
2021
Statut:
ppublish
Résumé
Corynebacterium pseudotuberculosis, a facultative intracellular bacterium, is an important zoonotic pathogen responsible for chronic inflammatory diseases. TRIM21, an E3 ubiquitin-protein ligase, plays pivotal roles in inflammation regulation. However, its role during C. pseudotuberculosis infection is unclear. Here, we found that TRIM21 expression was significantly increased in C. pseudotuberculosis-infected macrophages. Following infection by C. pseudotuberculosis, we observed a significantly higher number of bacteria and a higher degree of LDH release from Trim21
Identifiants
pubmed: 34425492
pii: S0378-1135(21)00232-7
doi: 10.1016/j.vetmic.2021.109209
pii:
doi:
Substances chimiques
Ribonucleoproteins
0
SS-A antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109209Informations de copyright
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