Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation.
Alzheimer’s disease
Amyloid-β
Mir17-92a
NBR1
autophagy
microRNA
microglia
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
05
2021
accepted:
30
06
2021
entrez:
24
8
2021
pubmed:
25
8
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and express low levels of autophagy cargo receptor NBR1. In 5xFAD mouse brains, we show for the first time that AD microglia express elevated levels of microRNA cluster Mirc1/Mir17-92a, which is known to downregulate autophagy proteins. By
Identifiants
pubmed: 34426734
doi: 10.3389/fimmu.2021.705581
pmc: PMC8379081
doi:
Substances chimiques
Amyloid beta-Peptides
0
MIRN17 microRNA, human
0
MicroRNAs
0
Mirn17 microRNA, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
705581Subventions
Organisme : NIA NIH HHS
ID : R21 AG067755
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG028271
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127651
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124121
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG064899
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Informations de copyright
Copyright © 2021 Estfanous, Daily, Eltobgy, Deems, Anne, Krause, Badr, Hamilton, Carafice, Hegazi, Abu Khweek, Kelani, Nimjee, Awad, Zhang, Cormet-Boyaka, Haffez, Soror, Mikhail, Nuovo, Barrientos, Gavrilin and Amer.
Déclaration de conflit d'intérêts
AM and GN were employed by Gnome Diagnostic. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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