Towards the sustainable discovery and development of new antibiotics.
Business strategy in drug development
Drug therapy
Journal
Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631
Informations de publication
Date de publication:
2021
2021
Historique:
accepted:
01
07
2021
pubmed:
25
8
2021
medline:
25
8
2021
entrez:
24
8
2021
Statut:
ppublish
Résumé
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
Identifiants
pubmed: 34426795
doi: 10.1038/s41570-021-00313-1
pii: 313
pmc: PMC8374425
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
726-749Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017702/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/J/000PR9790
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P007570/1
Pays : United Kingdom
Informations de copyright
© Springer Nature Limited 2021.
Déclaration de conflit d'intérêts
Competing interestsM. H. Medema is a co-founder of Design Pharmaceuticals and a member of the scientific advisory board of Hexagon Bio, and S. Donadio is a co-founder and shareholder of NAICONS, owning intellectual property on antibacterial compounds. The remaining authors do not declare any competing interests.
Références
Antimicrob Agents Chemother. 2000 Nov;44(11):3163-6
pubmed: 11036042
Nat Protoc. 2015 Oct;10(10):1567-93
pubmed: 26379230
Clin Infect Dis. 2021 May 18;72(10):e533-e541
pubmed: 32820807
Bioorg Med Chem. 2016 Dec 15;24(24):6390-6400
pubmed: 27887963
Nat Rev Microbiol. 2019 May;17(5):295-306
pubmed: 30837684
Front Med (Lausanne). 2017 Jan 19;3:75
pubmed: 28154815
Nat Microbiol. 2016 Apr 18;1:16051
pubmed: 27572649
Biosci Rep. 2019 Apr 12;39(4):
pubmed: 30910848
ACS Infect Dis. 2020 Jun 12;6(6):1313-1314
pubmed: 32527094
Science. 2015 Jun 5;348(6239):1106-12
pubmed: 26045430
Nat Prod Rep. 2019 Sep 18;36(9):1262-1280
pubmed: 30548045
Regul Toxicol Pharmacol. 2016 Jun;77:54-64
pubmed: 26879462
Biochem Biophys Res Commun. 1988 Feb 15;150(3):965-71
pubmed: 2449210
FEMS Microbiol Lett. 2018 Jul 1;365(13):
pubmed: 29860483
Anal Chem. 2018 Mar 6;90(5):3156-3164
pubmed: 29381867
Front Microbiol. 2019 Dec 02;10:2750
pubmed: 31849893
Mol Pharm. 2016 Feb 1;13(2):609-20
pubmed: 26696327
Expert Opin Pharmacother. 2020 Dec;21(17):2067-2071
pubmed: 32749893
ChemMedChem. 2019 Aug 20;14(16):1560-1572
pubmed: 31283109
Int J Mol Sci. 2019 Nov 21;20(23):
pubmed: 31766441
J Nat Prod. 2015 Oct 23;78(10):2505-9
pubmed: 26431157
Appl Microbiol Biotechnol. 2020 Sep;104(18):7777-7785
pubmed: 32780290
J Antimicrob Chemother. 2019 Jan 1;74(Suppl 1):i6-i15
pubmed: 30690540
Front Microbiol. 2019 May 07;10:943
pubmed: 31134007
Int J Mol Sci. 2020 Feb 18;21(4):
pubmed: 32085478
Sci Rep. 2019 Feb 20;9(1):2410
pubmed: 30787404
Handb Exp Pharmacol. 2016;232:235-60
pubmed: 26330260
Front Mol Biosci. 2017 Nov 22;4:74
pubmed: 29214156
Curr Med Chem. 2015;22(13):1603-30
pubmed: 25666805
Adv Drug Deliv Rev. 2016 Jun 1;101:89-98
pubmed: 27182629
Res Microbiol. 2018 Sep - Oct;169(7-8):425-431
pubmed: 29128373
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10124-10129
pubmed: 30228116
Adv Drug Deliv Rev. 2021 May;172:339-360
pubmed: 33705882
Nat Prod Rep. 2014 Jan;31(1):35-60
pubmed: 24142193
mBio. 2020 Jul 14;11(4):
pubmed: 32665275
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26936-26945
pubmed: 33046640
Nat Rev Microbiol. 2020 Aug;18(8):409-410
pubmed: 32488173
Nature. 2017 Nov 23;551(7681):457-463
pubmed: 29088705
J Cheminform. 2020 Apr 3;12(1):20
pubmed: 33431011
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Biotechnol Bioeng. 2019 Feb;116(2):364-374
pubmed: 30345503
ACS Infect Dis. 2020 Jun 12;6(6):1302-1304
pubmed: 32527097
Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14440-14475
pubmed: 29939462
Med Res Rev. 1996 Jan;16(1):3-50
pubmed: 8788213
Cell Chem Biol. 2016 Jul 21;23(7):862-874
pubmed: 27427232
Nucleic Acids Res. 2020 Jan 8;48(D1):D454-D458
pubmed: 31612915
Nat Rev Drug Discov. 2007 Jan;6(1):29-40
pubmed: 17159923
Ann Intensive Care. 2020 Sep 7;10(1):119
pubmed: 32894364
Nat Rev Microbiol. 2015 May;13(5):269-84
pubmed: 25853778
J Antimicrob Chemother. 2007 Dec;60(6):1206-15
pubmed: 17878146
Trends Mol Med. 2016 Jun;22(6):458-478
pubmed: 27178527
Cell. 2020 Apr 2;181(1):29-45
pubmed: 32197064
Chemistry. 2014 Aug 11;20(33):10204-12
pubmed: 25043880
Sci Rep. 2020 Mar 27;10(1):5563
pubmed: 32221330
Crit Rev Microbiol. 2015;41(4):465-72
pubmed: 24617440
BMC Biotechnol. 2017 Nov 14;17(1):81
pubmed: 29137618
ChemMedChem. 2020 Jan 17;15(2):188-194
pubmed: 31709767
Bull World Health Organ. 2020 Jul 1;98(7):442-442A
pubmed: 32742026
J Antibiot (Tokyo). 1985 Feb;38(2):145-52
pubmed: 2581926
Microb Cell Fact. 2020 Jan 9;19(1):5
pubmed: 31918711
Curr Opin Syst Biol. 2017 Aug;4:35-42
pubmed: 32715163
Metabolites. 2020 Jun 13;10(6):
pubmed: 32545768
ACS Chem Biol. 2016 Aug 19;11(8):2222-31
pubmed: 27193499
Trends Mol Med. 2017 Feb;23(2):135-149
pubmed: 28126271
ACS Omega. 2019 Feb 22;4(2):4049-4055
pubmed: 31459613
J Am Chem Soc. 2009 Sep 16;131(36):13031-6
pubmed: 19697908
Nat Rev Drug Discov. 2019 Nov;18(12):899-900
pubmed: 31780841
Curr Biol. 2019 Jun 3;29(11):R521-R537
pubmed: 31163166
ISME J. 2019 Feb;13(2):346-360
pubmed: 30250051
Lancet Infect Dis. 2016 Apr;16(4):500-5
pubmed: 27036356
Curr Drug Targets. 2021;22(5):555-572
pubmed: 32972338
J Am Chem Soc. 2017 Sep 13;139(36):12696-12703
pubmed: 28820255
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Nat Prod Rep. 2017 Jul 1;34(7):712-783
pubmed: 28650032
Nat Prod Rep. 2016 Feb;33(2):174-82
pubmed: 26647833
Sci Rep. 2019 Dec 27;9(1):20159
pubmed: 31882896
Chem Biol. 2014 Sep 18;21(9):1211-23
pubmed: 25237864
Appl Environ Microbiol. 2016 Feb 05;82(7):2210-8
pubmed: 26850294
Nat Prod Rep. 2019 Sep 1;36(9):1249-1261
pubmed: 31259995
Chem Biol. 2015 Jan 22;22(1):76-86
pubmed: 25556942
J Health Econ. 2016 May;47:20-33
pubmed: 26928437
BMC Bioinformatics. 2020 Feb 7;21(1):49
pubmed: 32033537
Nat Rev Microbiol. 2019 Mar;17(3):141-155
pubmed: 30683887
Lijec Vjesn. 1977 Sep;99(9):560-2
pubmed: 339024
Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8840-69
pubmed: 24990531
Metabolites. 2019 Jul 16;9(7):
pubmed: 31315242
Infect Control Hosp Epidemiol. 2020 Sep;41(9):1124-1125
pubmed: 32317036
Bioinformatics. 2020 Feb 15;36(4):1213-1218
pubmed: 31605112
Microbiology (Reading). 2013 Dec;159(Pt 12):2524-2532
pubmed: 24043447
J Am Chem Soc. 1970 Oct 7;92(20):6070-1
pubmed: 5459200
Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52
pubmed: 26438502
BMJ. 2020 May 18;369:m1983
pubmed: 32423901
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620951053
pubmed: 32873175
Cell. 2018 Jan 11;172(1-2):358-372.e23
pubmed: 29307493
J Med Chem. 2017 Aug 24;60(16):7108-7122
pubmed: 28749666
Analyst. 2019 Apr 8;144(8):2725-2735
pubmed: 30865733
J Antimicrob Chemother. 2018 Jun 1;73(6):1452-1459
pubmed: 29438542
J Antibiot (Tokyo). 2014 May;67(5):353-60
pubmed: 24569671
BMJ. 2018 Mar 8;360:k678
pubmed: 29519881
J Antibiot (Tokyo). 2017 Dec;70(12):1087-1096
pubmed: 29089600
Trends Biotechnol. 2018 Dec;36(12):1275-1286
pubmed: 30017093
Nat Rev Immunol. 2015 Aug;15(8):500-10
pubmed: 26160612
Curr Drug Targets. 2008 Sep;9(9):750-9
pubmed: 18781921
Science. 2016 Dec 16;354(6318):
pubmed: 27980159
Chem Biol. 2014 Sep 18;21(9):1115-42
pubmed: 25237858
BMJ. 2020 Jun 18;369:m2468
pubmed: 32554429
Acta Clin Belg Suppl. 1990;13:1-12
pubmed: 2239059
Nat Microbiol. 2020 Jun;5(6):787-795
pubmed: 32467623
Metab Eng. 2017 Nov;44:160-170
pubmed: 29030273
Antimicrob Agents Chemother. 2020 Oct 20;64(11):
pubmed: 32816693
Int J Antimicrob Agents. 2018 Oct;52(4):523-524
pubmed: 30092271
BMC Genomics. 2020 Mar 30;21(1):263
pubmed: 32228448
Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):135-137
pubmed: 30136219
Eur J Med Chem. 2020 Feb 15;188:112005
pubmed: 31911294
Bioinformatics. 2007 Dec 1;23(23):3256-7
pubmed: 17956876
J Med Chem. 2019 Jan 24;62(2):420-444
pubmed: 30035545
PLoS Biol. 2019 Jul 18;17(7):e3000347
pubmed: 31318855
Drug Discov Today. 2015 Feb;20(2):181-6
pubmed: 25205347
Lancet. 2020 Oct 3;396(10256):936-937
pubmed: 32896293
J Med Chem. 2013 Sep 12;56(17):6761-74
pubmed: 23919758
Pharmaceutics. 2017 Mar 27;9(2):
pubmed: 28346375
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12760-12764
pubmed: 28730677
Antimicrob Agents Chemother. 2009 Aug;53(8):3181-9
pubmed: 19451293
Metab Eng. 2019 Sep;55:201-211
pubmed: 31340171
J Med Chem. 2012 Mar 22;55(6):2532-7
pubmed: 22224562
PLoS Biol. 2020 Aug 18;18(8):e3000805
pubmed: 32810152
Clin Microbiol Infect. 2012 Mar;18(3):268-81
pubmed: 21793988
Nat Chem Biol. 2018 Jun;14(6):601-608
pubmed: 29662210
Nat Commun. 2015 Apr 24;6:6947
pubmed: 25907309
Nat Rev Drug Discov. 2010 Mar;9(3):203-14
pubmed: 20168317
Eur J Med Chem. 2014 Jan 24;72:26-34
pubmed: 24333612
Clin Microbiol Infect. 2020 Jul;26(7):808-810
pubmed: 32360446
Medchemcomm. 2019 May 8;10(5):682-692
pubmed: 31741728
Chemistry. 2020 Jan 2;26(1):49-88
pubmed: 31483909
Metab Eng. 2017 Jan;39:228-236
pubmed: 28013086
ACS Infect Dis. 2020 Jun 12;6(6):1317-1322
pubmed: 32202756
Mater Today Bio. 2020 Nov 02;8:100084
pubmed: 33313504
Beilstein J Org Chem. 2018 Oct 15;14:2627-2645
pubmed: 30410625
J Med Chem. 2009 Nov 12;52(21):6752-6
pubmed: 19827778
J Vis Exp. 2020 Oct 29;(164):
pubmed: 33191927
J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):129-41
pubmed: 26586404
Acc Chem Res. 2008 Nov 18;41(11):1534-44
pubmed: 18681463
Br J Pharmacol. 2011 May;163(1):184-94
pubmed: 21323894
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5970-5
pubmed: 27140646
Trends Microbiol. 2019 Apr;27(4):287-289
pubmed: 30638776
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
Elife. 2021 Mar 25;10:
pubmed: 33764297
Planta Med. 2020 Sep;86(13-14):891-905
pubmed: 32023633
NIDA Res Monogr. 1997;173:273-304
pubmed: 9260193
Nature. 2017 May 18;545(7654):299-304
pubmed: 28489819
AAPS J. 2012 Jun;14(2):262-81
pubmed: 22407287
Antimicrob Agents Chemother. 2018 Mar 27;62(4):
pubmed: 29358295
Nat Biotechnol. 2019 Oct;37(10):1110-1112
pubmed: 31578512
Curr Opin Microbiol. 2019 Oct;51:72-80
pubmed: 31733401
ChemMedChem. 2018 Mar 6;13(5):422-430
pubmed: 29334428
Trends Pharmacol Sci. 2017 Feb;38(2):143-154
pubmed: 27842887
Nat Chem. 2019 Jul;11(7):653-661
pubmed: 31182822
Nat Commun. 2020 Nov 27;11(1):6058
pubmed: 33247171
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9768-73
pubmed: 24965364
Methods Mol Biol. 2012;929:583-600
pubmed: 23007443
Sci Transl Med. 2020 Jun 24;12(549):
pubmed: 32581135
Nature. 2009 Jan 15;457(7227):332-5
pubmed: 18946472
Anal Chem. 2020 Dec 1;92(23):15403-15411
pubmed: 33171050
ACS Infect Dis. 2020 Jun 12;6(6):1286-1288
pubmed: 32527093
Antibiotics (Basel). 2020 Sep 18;9(9):
pubmed: 32962088
Molecules. 2019 Sep 11;24(18):
pubmed: 31514464
PLoS One. 2012;7(3):e33727
pubmed: 22470465
Medchemcomm. 2016 Jan 1;7(1):37-49
pubmed: 27746889
EMBO Mol Med. 2020 Jul 7;12(7):e12560
pubmed: 32453917
J Mol Biol. 2019 Aug 23;431(18):3472-3500
pubmed: 30959050
Biotechnol Lett. 2017 Jun;39(6):805-817
pubmed: 28275884
Front Artif Intell. 2020 Feb 28;3:4
pubmed: 33733124
Chem Rev. 2017 Apr 26;117(8):5619-5674
pubmed: 28106994
J Chem Inf Model. 2019 Oct 28;59(10):4450-4459
pubmed: 31518124
J Am Chem Soc. 2018 Feb 21;140(7):2537-2545
pubmed: 29272578
Nat Commun. 2019 Jul 22;10(1):3268
pubmed: 31332172
Magn Reson Chem. 2015 Aug;53(8):582-9
pubmed: 25998807
J Med Chem. 2018 Apr 12;61(7):2636-2651
pubmed: 28926247
PLoS Negl Trop Dis. 2020 Dec 7;14(12):e0008930
pubmed: 33284808
PLoS Med. 2017 Jul 26;14(7):e1002366
pubmed: 28746372
Annu Rev Biochem. 2019 Jun 20;88:383-408
pubmed: 30939043
Nat Chem Biol. 2015 Aug;11(8):536-41
pubmed: 26196764
Sci Rep. 2019 Apr 30;9(1):6666
pubmed: 31040339
Clin Microbiol Infect. 2020 Dec;26(12):1622-1629
pubmed: 32711058
Int J Antimicrob Agents. 2020 Dec;56(6):106179
pubmed: 32987104
Nat Prod Rep. 2017 Nov 15;34(11):1302-1331
pubmed: 29018846
Curr Drug Metab. 2006 Feb;7(2):165-82
pubmed: 16472106
J Med Chem. 2013 Feb 28;56(4):1363-88
pubmed: 23145854
Nat Chem Biol. 2015 Sep;11(9):639-48
pubmed: 26284671
Antimicrob Agents Chemother. 2020 Feb 21;64(3):
pubmed: 31907190
Sci Rep. 2018 Feb 8;8(1):2625
pubmed: 29422632
ACS Infect Dis. 2020 Jun 12;6(6):1292-1294
pubmed: 32527096
Clin Microbiol Rev. 1999 Oct;12(4):564-82
pubmed: 10515903
ACS Infect Dis. 2020 Jun 12;6(6):1311-1312
pubmed: 32527099
Pathogens. 2018 Feb 23;7(1):
pubmed: 29473841
Nucleic Acids Res. 2021 Jul 2;49(W1):W5-W14
pubmed: 33893803
J Chem Inf Model. 2015 Jul 27;55(7):1449-59
pubmed: 26052622
Nat Biotechnol. 2016 Aug 9;34(8):828-837
pubmed: 27504778
Br J Pharmacol. 2011 Mar;162(6):1239-49
pubmed: 21091654
Pharmacotherapy. 2020 May;40(5):487-488
pubmed: 32267566
Adv Biochem Eng Biotechnol. 2001;73:103-28
pubmed: 11816809
Sci Rep. 2017 Apr 25;7(1):1129
pubmed: 28442740
Nat Protoc. 2017 Nov;12(11):2391-2410
pubmed: 29072706
Nucleic Acids Res. 2018 Mar 16;46(5):e28
pubmed: 29240926
Nat Commun. 2018 Sep 27;9(1):3963
pubmed: 30262913
Integr Biol (Camb). 2017 Feb 20;9(2):109-122
pubmed: 28045163
Cell. 2020 Feb 20;180(4):688-702.e13
pubmed: 32084340
Nat Prod Rep. 2016 May 4;33(5):681-708
pubmed: 27098809
BMC Microbiol. 2016 May 10;16:82
pubmed: 27159970
mSystems. 2019 Jun 11;4(3):
pubmed: 31186311
Front Cell Infect Microbiol. 2019 Apr 02;9:74
pubmed: 31001485
IUBMB Life. 2017 Jun;69(6):442-450
pubmed: 28474474
Drug Discov Today. 2018 Sep;23(9):1578-1583
pubmed: 29753124
Antimicrob Agents Chemother. 2012 Nov;56(11):5433-41
pubmed: 22850518
Nat Commun. 2018 Jan 2;9(1):22
pubmed: 29295973
Int J Antimicrob Agents. 2020 Apr;55(4):105944
pubmed: 32179150
Clin Infect Dis. 2020 Dec 3;71(9):2459-2468
pubmed: 32358954
J Am Chem Soc. 2008 Dec 31;130(52):17913-27
pubmed: 19053822
J Med Chem. 2016 Jul 14;59(13):5929-69
pubmed: 26804741
Essays Biochem. 2017 Mar 3;61(1):127-139
pubmed: 28258236
Nat Microbiol. 2019 Dec;4(12):2498-2510
pubmed: 31611640
Biochemistry (Mosc). 2005 Nov;70(11):1199-211
pubmed: 16336178
Chem Biol Drug Des. 2015 Jan;85(1):14-21
pubmed: 25521642
ACS Chem Biol. 2019 Mar 15;14(3):468-477
pubmed: 30747520
J Infect Dis. 2012 Jul 15;206(2):249-57
pubmed: 22586066
Nat Commun. 2019 Jul 31;10(1):3416
pubmed: 31366924
ACS Cent Sci. 2019 Nov 27;5(11):1824-1833
pubmed: 31807684
ACS Infect Dis. 2018 Aug 10;4(8):1188-1196
pubmed: 29750862
Sci Rep. 2017 Sep 7;7(1):10767
pubmed: 28883399
Drugs. 2020 Sep;80(13):1309-1318
pubmed: 32691293
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16169-74
pubmed: 24046367
Ups J Med Sci. 2014 May;119(2):162-9
pubmed: 24646082
Antioxid Redox Signal. 2013 Mar 1;18(7):743-55
pubmed: 22937752
Nat Rev Drug Discov. 2020 May;19(5):353-364
pubmed: 31801986
Int J Mol Sci. 2020 Jun 27;21(13):
pubmed: 32605029
Antimicrob Agents Chemother. 2019 Oct 22;63(11):
pubmed: 31451507
ACS Synth Biol. 2013 Jul 19;2(7):384-96
pubmed: 23654282
Curr Pharm Des. 2016;22(21):3171-81
pubmed: 26907941
Angew Chem Int Ed Engl. 2020 Jun 2;59(23):8823-8827
pubmed: 32190958
Brief Bioinform. 2021 Jan 18;22(1):247-269
pubmed: 31950972
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
Nature. 2018 Jun;558(7710):440-444
pubmed: 29899444
Nat Prod Rep. 2017 Jul 6;34(7):784-814
pubmed: 28561849
J Biomol Screen. 2013 Oct;18(9):1018-26
pubmed: 23686103
Drug Dev Res. 2019 Feb;80(1):6-10
pubmed: 30312991
Nucleic Acids Res. 2020 Jul 2;48(W1):W546-W552
pubmed: 32427317
ACS Infect Dis. 2020 Jun 12;6(6):1295-1298
pubmed: 32406675
FEMS Microbiol Rev. 2019 Sep 1;43(5):490-516
pubmed: 31150547
Nature. 2016 Jul 27;535(7613):511-6
pubmed: 27466123
Sci Rep. 2019 Mar 5;9(1):3452
pubmed: 30837499
Nat Rev Microbiol. 2020 May;18(5):267-274
pubmed: 31745330
J Med Chem. 2008 May 22;51(10):2871-8
pubmed: 18260614
Adv Drug Deliv Rev. 2016 Jun 1;101:34-41
pubmed: 27154268
Beilstein J Org Chem. 2018 Oct 11;14:2607-2617
pubmed: 30410623
Curr Top Med Chem. 2014;14(11):1356-64
pubmed: 24805064
Proc West Pharmacol Soc. 2009;52:94-8
pubmed: 22128433
Nat Chem Biol. 2016 Apr;12(4):233-9
pubmed: 26829473
J Antibiot (Tokyo). 2018 Feb;71(2):318-325
pubmed: 29018266
BMC Infect Dis. 2020 Sep 1;20(1):646
pubmed: 32873235
Mitochondrion. 2014 May;16:50-4
pubmed: 24246912
Nat Commun. 2020 Mar 19;11(1):1455
pubmed: 32193379
Cell Rep. 2015 Mar 17;10(10):1681-1691
pubmed: 25772356
Chem Sci. 2018 May 3;9(21):4898-4908
pubmed: 29910943
Metab Eng. 2018 Sep;49:316-324
pubmed: 30196100
Clin Gastroenterol Hepatol. 2014 Oct;12(10):1605-10
pubmed: 24981782
Nat Prod Rep. 2019 Oct 16;36(10):1412-1436
pubmed: 30620035
Sci Rep. 2017 Dec 12;7(1):17419
pubmed: 29234001
Nat Rev Microbiol. 2020 May;18(5):275-285
pubmed: 31745331
Nature. 2014 Jun 26;510(7506):503-6
pubmed: 24965651
J Med Chem. 2019 May 9;62(9):4411-4425
pubmed: 31009558
Nature. 2015 Jan 22;517(7535):455-9
pubmed: 25561178
Curr Top Med Chem. 2005;5(11):1033-8
pubmed: 16181128
Cell Host Microbe. 2019 Jul 10;26(1):61-72
pubmed: 31295426
Antimicrob Agents Chemother. 2021 Feb 22;:
pubmed: 33619062
Eur J Drug Metab Pharmacokinet. 1993 Jan-Mar;18(1):49-59
pubmed: 8335039
Infect Immun. 2019 Aug 21;87(9):
pubmed: 31262983
Microb Biotechnol. 2011 Mar;4(2):207-15
pubmed: 21342466
Curr Drug Metab. 2007 Jun;8(5):463-79
pubmed: 17584017
Lancet Infect Dis. 2020 Oct;20(10):1172-1181
pubmed: 32505231
Appl Microbiol Biotechnol. 2018 Sep;102(17):7333-7341
pubmed: 29974183
Nat Prod Rep. 2019 Sep 1;36(9):1313-1332
pubmed: 31197291
Chem Biol Interact. 2019 Aug 1;308:294-303
pubmed: 31158333
Antimicrob Agents Chemother. 2017 Jun 27;61(7):
pubmed: 28461320
Metabolites. 2020 Apr 09;10(4):
pubmed: 32283661
Expert Rev Clin Pharmacol. 2013 Jan;6(1):41-7
pubmed: 23272792
Nat Rev Drug Discov. 2020 May;19(5):298
pubmed: 32269310
Chemistry. 2010 Nov 8;16(42):12512-25
pubmed: 20845412
J Nat Prod. 2017 Jun 23;80(6):1758-1766
pubmed: 28616931
Nature. 2019 Dec;576(7787):459-464
pubmed: 31747680
Microorganisms. 2019 Jun 22;7(6):
pubmed: 31234491
Expert Opin Drug Discov. 2012 Jul;7(7):633-42
pubmed: 22607346
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3937-40
pubmed: 25650563
Nat Rev Microbiol. 2017 Oct 12;15(11):675-687
pubmed: 29021598
Nat Commun. 2018 Feb 23;9(1):803
pubmed: 29476047
Adv Sci (Weinh). 2021 Jun;8(12):e2004369
pubmed: 34165899
Clin Microbiol Infect. 2018 Aug;24(8):801-802
pubmed: 29649600
BMC Public Health. 2019 Oct 30;19(1):1425
pubmed: 31666056
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11054-9
pubmed: 26216986
Front Mol Biosci. 2020 May 15;7:87
pubmed: 32500080
Antimicrob Agents Chemother. 2020 Jan 27;64(2):
pubmed: 31740560
Front Microbiol. 2019 Jun 20;10:1404
pubmed: 31281299
Clin Infect Dis. 2021 May 4;72(9):1657-1659
pubmed: 32544232
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7266-71
pubmed: 24808135
Pharmaceutics. 2019 Jan 19;11(1):
pubmed: 30669434
Nucleic Acids Res. 2019 Jul 2;47(W1):W81-W87
pubmed: 31032519
J Bacteriol. 2013 May;195(10):2309-21
pubmed: 23475977