Breast MRI during Neoadjuvant Chemotherapy: Lack of Background Parenchymal Enhancement Suppression and Inferior Treatment Response.
Adult
Aged
Breast
/ diagnostic imaging
Breast Neoplasms
/ diagnostic imaging
Chemotherapy, Adjuvant
/ methods
Cohort Studies
Contrast Media
Female
Humans
Image Enhancement
/ methods
Magnetic Resonance Imaging
/ methods
Middle Aged
Neoadjuvant Therapy
/ methods
Retrospective Studies
Treatment Outcome
Young Adult
Journal
Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
pubmed:
25
8
2021
medline:
30
11
2021
entrez:
24
8
2021
Statut:
ppublish
Résumé
Background Suppression of background parenchymal enhancement (BPE) is commonly observed after neoadjuvant chemotherapy (NAC) at contrast-enhanced breast MRI. It was hypothesized that nonsuppressed BPE may be associated with inferior response to NAC. Purpose To investigate the relationship between lack of BPE suppression and pathologic response. Materials and Methods A retrospective review was performed for women with menopausal status data who were treated for breast cancer by one of 10 drug arms (standard NAC with or without experimental agents) between May 2010 and November 2016 in the Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis 2, or I-SPY 2 TRIAL (NCT01042379). Patients underwent MRI at four points: before treatment (T0), early treatment (T1), interregimen (T2), and before surgery (T3). BPE was quantitatively measured by using automated fibroglandular tissue segmentation. To test the hypothesis effectively, a subset of examinations with BPE with high-quality segmentation was selected. BPE change from T0 was defined as suppressed or nonsuppressed for each point. The Fisher exact test and the
Identifiants
pubmed: 34427465
doi: 10.1148/radiol.2021203645
pmc: PMC8574064
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
295-308Subventions
Organisme : NCI NIH HHS
ID : R01 CA227763
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA197000
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA132870
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233302
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA151235
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA210961
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
Radiology. 1997 Apr;203(1):145-9
pubmed: 9122383
J Magn Reson Imaging. 2020 Jan;51(1):43-61
pubmed: 31004391
Acta Radiol. 2018 Jul;59(7):806-812
pubmed: 29065702
Nat Rev Cancer. 2006 Nov;6(11):886-93
pubmed: 17036039
Cancer Res. 2004 Feb 1;64(3):821-4
pubmed: 14871806
Radiographics. 2014 Jan-Feb;34(1):234-47
pubmed: 24428293
Am J Surg. 2006 Oct;192(4):520-4
pubmed: 16978965
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:1667-70
pubmed: 17272023
Cancer. 2005 Oct 15;104(8):1575-9
pubmed: 16134178
Radiology. 2017 Dec;285(3):788-797
pubmed: 28914599
Transl Oncol. 2015 Jun;8(3):204-9
pubmed: 26055178
AJR Am J Roentgenol. 2015 Mar;204(3):669-73
pubmed: 25714301
Am J Clin Oncol. 2007 Apr;30(2):126-32
pubmed: 17414460
Radiology. 2012 Sep;264(3):670-8
pubmed: 22771878
Eur Radiol. 2018 Nov;28(11):4705-4716
pubmed: 29736850
N Engl J Med. 2005 Jun 2;352(22):2302-13
pubmed: 15930421
Radiology. 2007 Aug;244(2):356-78
pubmed: 17641361
Lancet. 2015 Oct 3;386(10001):1341-1352
pubmed: 26211827
Radiology. 2015 Dec;277(3):687-96
pubmed: 26176656
Breast Cancer Res Treat. 2009 May;115(2):335-42
pubmed: 18506620
Eur Radiol. 2016 Jun;26(6):1590-6
pubmed: 26382845
Breast J. 2012 Nov-Dec;18(6):527-34
pubmed: 23002953
Tomography. 2020 Jun;6(2):101-110
pubmed: 32548286
Cancer. 2010 Feb 15;116(4):791-8
pubmed: 20052714
Br J Radiol. 2018 Jul;91(1088):20170550
pubmed: 29848015
Transl Oncol. 2017 Oct;10(5):786-792
pubmed: 28806712
Radiology. 1997 Apr;203(1):137-44
pubmed: 9122382
Cancer Res. 2005 Mar 15;65(6):2433-40
pubmed: 15781659
J Magn Reson Imaging. 2011 May;33(5):1229-34
pubmed: 21509883
N Engl J Med. 2006 Jan 19;354(3):270-82
pubmed: 16421368
Breast J. 2005 Jul-Aug;11(4):236-41
pubmed: 15982388
Lancet. 2011 Aug 27;378(9793):771-84
pubmed: 21802721
N Engl J Med. 2018 Jul 12;379(2):122-137
pubmed: 29863451