Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.
Adult
Age of Onset
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ metabolism
Cognition
Diffusion Tensor Imaging
Down Syndrome
/ complications
Exercise
/ physiology
Female
Humans
Male
Middle Aged
Neuroimaging
Positron-Emission Tomography
Risk
Sedentary Behavior
White Matter
/ diagnostic imaging
tau Proteins
/ metabolism
Alzheimer's disease
Biomarkers
Cognitive functioning
Down syndrome
Physical activity
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
11
02
2021
revised:
22
07
2021
accepted:
22
07
2021
pubmed:
25
8
2021
medline:
27
1
2022
entrez:
24
8
2021
Statut:
ppublish
Résumé
Adults with Down syndrome (DS) are at risk for Alzheimer's disease. Despite sharing trisomy 21, however, there is variability in the age of disease onset. This variability may mean that other factors, such as lifestyle, influence cognitive aging and disease timing. The present study assessed the association between everyday life physical activity using an actigraph accelerometer and cognitive functioning and early Alzheimer's disease pathology via positron emission tomography amyloid-β and tau and diffusion tension imaging measures of white matter integrity in 61 non-demented adults with DS. Percent time in sedentary behavior and in moderate-to-vigorous activity were associated (negatively and positively, respectively) with cognitive functioning (r = -.472 to .572, p < 0.05). Neither sedentary behavior nor moderate-to-vigorous activity were associated with amyloid-β or tau, but both were associated with white matter integrity in the superior and inferior longitudinal fasciculus (Fractional Anisotropy: r = -.397 to -.419, p < 0.05; Mean Diffusivity: r = .400, p < 0.05). Longitudinal studies are needed to determine if physical activity promotes healthy aging in DS.
Identifiants
pubmed: 34428720
pii: S0197-4580(21)00242-6
doi: 10.1016/j.neurobiolaging.2021.07.016
pmc: PMC8641014
mid: NIHMS1755660
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-127Subventions
Organisme : NIA NIH HHS
ID : R01 AG070028
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG068054
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105353
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031110
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG051406
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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