A Meta-Analysis in Assessing Oxidative Stress Using Malondialdehyde in Oral Submucous Fibrosis.

This study aimed to evaluate the oxidative stress (OS) marker Malondialdehyde (MDA) in oral submucous fibrosis with available literature. We conducted a literature search electronically in PubMed (MeSH), Science Direct, Scopus, and Google Scholar using specific keywords. A systematic search in PubMed, Science Direct, and Google Scholar identified 334 articles. Of these, four were duplicate reports, and three were animal studies. After reading the abstracts of the collected articles, 288 articles were excluded for the following reasons: low quality, not relevant to the research question, or did not meet the inclusion criteria. The remaining 46 articles were chosen for full-text assessment. Finally, the present qualitative synthesis included 23 articles for evaluation. The selected studies in MDA analysis in a random-effects model showed higher heterogeneity (Q = 477.636, The selected studies showed significantly higher MDA levels in various biological samples of patients with OSMF. Therefore, further studies are needed to estimate oxidative stress levels by using different biomarkers in OSMF to direct future therapy.

Informations de copyright

European Journal of Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Déclaration de conflit d'intérêts

None declared.K.M., C.K., and S.P. performed the data collection procedure. K.M., C.K., and N.J. screened the titles/abstracts and excluded studies at high risk of bias from the evidence synthesis based on prespecified exclusion criteria to avoid introducing bias. K.M., C.K., and S.P. independently screened each included study’s full texts for eligibility. All the authors checked and discussed the relevant factors considered in each included study. The authors resolved disagreements by consensus. Finally, all the authors read and accepted the potentially included articles. K.M. wrote the initial draft of the manuscript. K.C. and N.J. participated in the manuscript revision. S.P., R.T., and L.S. reviewed the charts and final revision of the manuscript. The authors read and approved the final manuscript.