The Protective Effect of Docosahexaenoic Acid on PC12 Cells in Oxidative Stress Induced by H

Animals Cyclic AMP Response Element-Binding Protein / metabolism Docosahexaenoic Acids / pharmacology Hydrogen Peroxide / toxicity MAP Kinase Signaling System Oxidative Stress PC12 Cells Rats
Docosahexaenoic acid mitochondria neurite outgrowth neuroprotective activity neurotransmitters oxidative damage

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
15 09 2021
Historique:
pubmed: 26 8 2021
medline: 21 9 2021
entrez: 25 8 2021
Statut: ppublish

Résumé

Docosahexaenoic acid (DHA) has attracted plenty of interest in the prevention of neurodegenerative diseases. Although the beneficial effects of DHA on the central nervous system function are recognized, more information on the molecular mechanisms involved in its neuroprotective effects is required. The present study aimed to evaluate the effects of DHA on the function of mitochondria, neurite growth-related proteins signaling pathway, and neural signal transmission. In this study, PC12 cells were treated with H

Identifiants

DOI: 10.1021/acschemneuro.1c00421 PMID: 34428890
pubmed: 34428890
doi: 10.1021/acschemneuro.1c00421
doi:

Substances chimiques

Cyclic AMP Response Element-Binding Protein 0
Docosahexaenoic Acids 25167-62-8
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3433-3444

Auteurs

Nana Bie (N)

"State Key Laboratory of Food Nutrition and Safety", Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.

Xiaojuan Feng (X)

"State Key Laboratory of Food Nutrition and Safety", Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.

Chenjing Li (C)

"State Key Laboratory of Food Nutrition and Safety", Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.

Meng Meng (M)

"State Key Laboratory of Food Nutrition and Safety", Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.

Chunling Wang (C)

"State Key Laboratory of Food Nutrition and Safety", Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.
ORCID: 0000-0002-4187-6098

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide docosahexaénoïque › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Cellules › Cellules chromaffines › Cellules PC12 › The Protective Effect of Docosahexaenoic Acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The Protective Effect of Docosahexaenoic Acid...