The global molecular epidemiology of microsporidia infection in sheep and goats with focus on Enterocytozoon bieneusi: a systematic review and meta-analysis.
Enterocytozoon bieneusi
Goat
Meta-analysis
Microsporidia
Sheep
Journal
Tropical medicine and health
ISSN: 1348-8945
Titre abrégé: Trop Med Health
Pays: Japan
ID NLM: 101215093
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
received:
18
05
2021
accepted:
16
08
2021
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
Microsporidia is a zoonotic pathogen with health consequences in immunocompromised patients. Small ruminants are a potential reservoir of microsporidia for humans in their vicinity. Hence, we aimed to evaluate the molecular prevalence of microsporidian infections with emphasis on Enterocytozoon bieneusi genotypes among sheep and goats at a global scale through systematic review and meta-analysis approach. The standard protocol of preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed. Eligible prevalence studies on small ruminant microsporidiosis, published from 1 January 2000 until 15 April 2021 were gathered using systematic literature search in PubMed, Scopus, Web of Science and Google Scholar databases. Inclusion and exclusion criteria were applied. The point estimates and 95% confidence intervals were calculated using a random-effects model. The variance between studies (heterogeneity) was quantified by I In total, 25 articles (including 34 datasets) were included for final meta-analysis. The pooled molecular prevalence of microsporidia in sheep and goats was estimated to be 17.4% (95% CI: 11.8-25%) and 16% (95% CI: 11.2-22.4%), respectively. Likewise, the overall prevalence of E. bieneusi was estimated to be 17.4% (95% CI: 11.8-25%) for sheep and 16.3% (95% CI: 11.3-22.8%) for goats. According to internal transcribed spacer (ITS) gene analysis, E. bieneusi with genotypes BEB6 (15 studies) and COS-1 (nine studies) in sheep, and CHG3 (six studies) and BEB6 (five studies) in goats were the highest reported genotypes. The present results highlight the role of sheep and goats as reservoir hosts for human-infecting microsporidia. Therefore, this global estimate could be beneficial on preventive and control measures.
Sections du résumé
BACKGROUND
BACKGROUND
Microsporidia is a zoonotic pathogen with health consequences in immunocompromised patients. Small ruminants are a potential reservoir of microsporidia for humans in their vicinity. Hence, we aimed to evaluate the molecular prevalence of microsporidian infections with emphasis on Enterocytozoon bieneusi genotypes among sheep and goats at a global scale through systematic review and meta-analysis approach.
METHODS
METHODS
The standard protocol of preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed. Eligible prevalence studies on small ruminant microsporidiosis, published from 1 January 2000 until 15 April 2021 were gathered using systematic literature search in PubMed, Scopus, Web of Science and Google Scholar databases. Inclusion and exclusion criteria were applied. The point estimates and 95% confidence intervals were calculated using a random-effects model. The variance between studies (heterogeneity) was quantified by I
RESULTS
RESULTS
In total, 25 articles (including 34 datasets) were included for final meta-analysis. The pooled molecular prevalence of microsporidia in sheep and goats was estimated to be 17.4% (95% CI: 11.8-25%) and 16% (95% CI: 11.2-22.4%), respectively. Likewise, the overall prevalence of E. bieneusi was estimated to be 17.4% (95% CI: 11.8-25%) for sheep and 16.3% (95% CI: 11.3-22.8%) for goats. According to internal transcribed spacer (ITS) gene analysis, E. bieneusi with genotypes BEB6 (15 studies) and COS-1 (nine studies) in sheep, and CHG3 (six studies) and BEB6 (five studies) in goats were the highest reported genotypes.
CONCLUSION
CONCLUSIONS
The present results highlight the role of sheep and goats as reservoir hosts for human-infecting microsporidia. Therefore, this global estimate could be beneficial on preventive and control measures.
Identifiants
pubmed: 34429166
doi: 10.1186/s41182-021-00355-7
pii: 10.1186/s41182-021-00355-7
pmc: PMC8385986
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
66Informations de copyright
© 2021. The Author(s).
Références
Appl Environ Microbiol. 2015 May 15;81(10):3326-35
pubmed: 25746997
Infect Genet Evol. 2018 Nov;65:385-391
pubmed: 30145389
J Eukaryot Microbiol. 2009 Jan-Feb;56(1):34-8
pubmed: 19335772
Small Rumin Res. 2001 Apr;40(1):1-11
pubmed: 11259871
Infect Genet Evol. 2015 Jun;32:265-70
pubmed: 25818401
Vet Parasitol. 2015 Jun 15;210(3-4):235-9
pubmed: 25944405
Parasitol Res. 2018 Mar;117(3):721-727
pubmed: 29332156
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Res Vet Sci. 2016 Aug;107:196-201
pubmed: 27473995
Int J Food Microbiol. 2020 Dec 2;334:108828
pubmed: 32866940
Parasite. 2008 Sep;15(3):349-58
pubmed: 18814706
Acta Trop. 2019 Mar;191:217-220
pubmed: 30586572
Infect Genet Evol. 2020 Nov;85:104559
pubmed: 32961363
Infect Agent Cancer. 2020 Jul 22;15:48
pubmed: 32704306
Trends Parasitol. 2016 Apr;32(4):336-348
pubmed: 26796229
Iran J Parasitol. 2015 Jul-Sep;10(3):381-8
pubmed: 26622293
Parasit Vectors. 2018 Jan 9;11(1):28
pubmed: 29316950
Acta Parasitol. 2019 Mar;64(1):44-50
pubmed: 30645740
PLoS One. 2014 May 20;9(5):e97623
pubmed: 24845247
Infect Genet Evol. 2018 Oct;64:46-51
pubmed: 29894792
Acta Trop. 2018 Sep;185:193-203
pubmed: 29802845
Parasitol Res. 2015 Mar;114(3):843-50
pubmed: 25547075
Parasit Vectors. 2016 Jan 19;9:23
pubmed: 26782742
Mem Inst Oswaldo Cruz. 2002 Oct;97(7):941-5
pubmed: 12471418
J Eukaryot Microbiol. 2020 Jan;67(1):100-106
pubmed: 31442347
Parasitol Res. 2019 Sep;118(9):2729-2734
pubmed: 31321521
Vet Parasitol. 2014 Sep 15;205(1-2):371-4
pubmed: 24986434
Microb Pathog. 2021 May;154:104828
pubmed: 33744336
BMC Vet Res. 2019 Aug 28;15(1):308
pubmed: 31462318
Parasit Vectors. 2018 Nov 12;11(1):587
pubmed: 30419954
Acta Trop. 2018 Jul;183:142-152
pubmed: 29660311
PLoS One. 2016 Nov 10;11(11):e0166320
pubmed: 27832178
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Acta Trop. 2005 Apr;94(1):61-76
pubmed: 15777637
Comp Immunol Microbiol Infect Dis. 2019 Aug;65:116-123
pubmed: 31300099
Int J Hyg Environ Health. 2018 May;221(4):642-651
pubmed: 29627259
Prev Vet Med. 2021 Mar;188:105278
pubmed: 33548904
Foodborne Pathog Dis. 2021 May 11;:
pubmed: 33978456
Infect Genet Evol. 2016 Jul;41:26-31
pubmed: 27017915
Curr Opin Infect Dis. 2006 Oct;19(5):485-92
pubmed: 16940873
Parasitol Int. 2019 Aug;71:80-86
pubmed: 30974206
Iran J Parasitol. 2016 Apr-Jun;11(2):195-203
pubmed: 28096853
Acta Parasitol. 2021 Jun 27;:
pubmed: 34176043
Water Res. 2011 Oct 15;45(16):4837-43
pubmed: 21774958
Iran J Parasitol. 2014 Apr-Jun;9(2):149-54
pubmed: 25848379
Parasite. 2019;26:62
pubmed: 31670656
Comp Immunol Microbiol Infect Dis. 2019 Dec;67:101346
pubmed: 31550674
Acta Trop. 2001 Feb 23;78(2):89-102
pubmed: 11230819