Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 08 2021
24 08 2021
Historique:
received:
16
02
2021
accepted:
14
07
2021
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 patient-derived xenograft (PDX) models across 25 cancer types, together with mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared with human tumors, PDXs typically have higher purity and fit to investigate dynamic driver events and molecular properties via multiple time points from same case PDXs. Here, we report on dynamic genomic landscapes and pharmacogenomic associations, including associations between activating oncogenic events and drugs, correlations between whole-genome duplications and subclone events, and the potential PDX models for NCI-MATCH trials. Lastly, we provide a web portal having comprehensive pan-cancer PDX genomic profiles and source code to facilitate identification of more druggable events and further insights into PDXs' recapitulation of human tumors.
Identifiants
pubmed: 34429404
doi: 10.1038/s41467-021-25177-3
pii: 10.1038/s41467-021-25177-3
pmc: PMC8384880
doi:
Banques de données
figshare
['10.6084/m9.figshare.14390408']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5086Subventions
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA233223
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003167
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201400008C
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA237732
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA224067
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224070
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224076
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224065
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA233306
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224083
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003C
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA070907
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003I
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States
Investigateurs
Julie Belmar
(J)
Jason Held
(J)
Jingqin Luo
(J)
Brian A Van Tine
(BA)
Rose Tipton
(R)
Yige Wu
(Y)
Lijun Yao
(L)
Daniel Cui Zhou
(DC)
Andrew Butterfield
(A)
Zhengtao Chu
(Z)
Maihi Fujita
(M)
Chieh-Hsiang Yang
(CH)
Emilio Cortes-Sanchez
(E)
Sandra Scherer
(S)
Ling Zhao
(L)
Tijana Borovski
(T)
Vicki Chin
(V)
John DiGiovanna
(J)
Christian Frech
(C)
Jeffrey Grover
(J)
Ryan Jeon
(R)
Soner Koc
(S)
Jelena Randjelovic
(J)
Sara Seepo
(S)
Tamara Stankovic
(T)
Lacey E Dobrolecki
(LE)
Michael Ittmann
(M)
Susan G Hilsenbeck
(SG)
Bert W O'Malley
(BW)
Nicholas Mitsiades
(N)
Salma Kaochar
(S)
Argun Akcakanat
(A)
Jithesh Augustine
(J)
Huiqin Chen
(H)
Bingbing Dai
(B)
Kurt W Evans
(KW)
Kelly Gale
(K)
Don Gibbons
(D)
Min Jin Ha
(MJ)
Vanessa Jensen
(V)
Michael Kim
(M)
Bryce P Kirby
(BP)
Scott Kopetz
(S)
Christopher D Lanier
(CD)
Dali Li
(D)
Mourad Majidi
(M)
David Menter
(D)
Ismail Meraz
(I)
Turcin Saridogan
(T)
Stephen Scott
(S)
Alexey Sorokin
(A)
Coya Tapia
(C)
Jing Wang
(J)
Shannon Westin
(S)
Yuanxin Xi
(Y)
Yi Xu
(Y)
Fei Yang
(F)
Timothy A Yap
(TA)
Vashisht G Yennu-Nanda
(VG)
Erkan Yuca
(E)
Jianhua Zhang
(J)
Ran Zhang
(R)
Xiaoshan Zhang
(X)
Xiaofeng Zheng
(X)
Dylan Fingerman
(D)
Haiyin Lin
(H)
Qin Liu
(Q)
Andrew V Kossenkov
(AV)
Vito W Rebecca
(VW)
Rajasekharan Somasundaram
(R)
Michae T Tetzlaff
(MT)
Jayamanna Wickramasinghe
(J)
Min Xiao
(M)
Xiaowei Xu
(X)
Carol J Bult
(CJ)
Peter N Robinson
(PN)
Anuj Srivastava
(A)
Michael W Lloyd
(MW)
Steven B Neuhauser
(SB)
Jill Rubinstein
(J)
Brian J Sanderson
(BJ)
Brian White
(B)
Xing Yi Woo
(XY)
Tiffany Wallace
(T)
John D Minna
(JD)
Gao Boning
(G)
Luc Girard
(L)
Hyunsil Park
(H)
Brenda C Timmons
(BC)
Katherine L Nathanson
(KL)
George Xu
(G)
Chong-Xian Pan
(CX)
Moon S Chen
(MS)
Luis G Carvajal-Carmona
(LG)
May Cho
(M)
Nicole B Coggins
(NB)
Ralph W deVere White
(RWD)
Guadalupe Polanco-Echeverry
(G)
Ana Estrada
(A)
David R Gandara
(DR)
Amanda R Kirane
(AR)
Tiffany Le
(T)
Paul Lott
(P)
Alexa Morales Arana
(AM)
Jonathan W Reiss
(JW)
Sienna Rocha
(S)
Clifford G Tepper
(CG)
Ted Toal
(T)
Hongyong Zhang
(H)
Ai-Hong Ma
(AH)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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