Methotrexate-Induced Leukocytoclastic Vasculitis.
cancer
chemotherapy
child
rash
vasculitis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
accepted:
17
07
2021
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
Erythematous tender cutaneous lesions developed in a 10-year-old child of acute leukemia receiving oral methotrexate and 6-mercaptopurine during maintenance phase of chemotherapy. She was also found to have coagulopathy and transaminitis. Differential clinical diagnosis included infectious processes, pyoderma gangrenosum, connective tissue disorders like rheumatoid neutrophilic dermatitis, and drug-induced side effects. Oral methotrexate was withheld following which the lesions subsided. Skin biopsy revealed a diagnosis of leukocytoclastic vasculitis. Cutaneous vasculitis is a rare side effect of methotrexate and its possibility should be considered in any patient who develops skin lesions while being receiving chemotherapy.
Identifiants
pubmed: 34430130
doi: 10.7759/cureus.16519
pmc: PMC8374989
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e16519Informations de copyright
Copyright © 2021, Dewan et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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