Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP.
ICD
Primary prevention
VT
Journal
Heart rhythm O2
ISSN: 2666-5018
Titre abrégé: Heart Rhythm O2
Pays: United States
ID NLM: 101768511
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
The value of antitachycardia pacing (ATP) in the overall cohort of primary prevention patients who receive implantable cardioverter-defibrillators (ICDs) remains uncertain. ATP success reported in prior trials potentially included a large number of patients receiving unnecessary ATP for arrhythmias that may have self-terminated owing to the prematurity of the intervention. Although some patients derive benefit from initial ATP in terminating rapid ventricular arrhythmias and thereby preventing shocks, there are limited data allowing us to identify those patients The purpose of APPRAISE ATP is to understand the role of ATP in primary prevention patients currently indicated for ICD therapy in a large prospective randomized controlled trial with modern programming parameters. The study is a global, prospective, randomized, multicenter clinical trial conducted at up to 150 sites globally, enrolling approximately 2600 subjects The primary endpoint of the trial is An Electrogram and Device Interrogation Core Laboratory will review interrogation data to determine primary endpoints that occur in APPRAISE ATP. Their decisions are based on independent physician review of the data from device interrogation. The ultimate purpose of the study is to aid clinicians in the selection of ICD technologies based on hard endpoint evidence across the spectrum of indications for primary prevention implantation.
Sections du résumé
BACKGROUND
BACKGROUND
The value of antitachycardia pacing (ATP) in the overall cohort of primary prevention patients who receive implantable cardioverter-defibrillators (ICDs) remains uncertain. ATP success reported in prior trials potentially included a large number of patients receiving unnecessary ATP for arrhythmias that may have self-terminated owing to the prematurity of the intervention. Although some patients derive benefit from initial ATP in terminating rapid ventricular arrhythmias and thereby preventing shocks, there are limited data allowing us to identify those patients
OBJECTIVE
OBJECTIVE
The purpose of APPRAISE ATP is to understand the role of ATP in primary prevention patients currently indicated for ICD therapy in a large prospective randomized controlled trial with modern programming parameters.
METHODS
METHODS
The study is a global, prospective, randomized, multicenter clinical trial conducted at up to 150 sites globally, enrolling approximately 2600 subjects The primary endpoint of the trial is
RESULTS
RESULTS
An Electrogram and Device Interrogation Core Laboratory will review interrogation data to determine primary endpoints that occur in APPRAISE ATP. Their decisions are based on independent physician review of the data from device interrogation.
CONCLUSION
CONCLUSIONS
The ultimate purpose of the study is to aid clinicians in the selection of ICD technologies based on hard endpoint evidence across the spectrum of indications for primary prevention implantation.
Identifiants
pubmed: 34430946
doi: 10.1016/j.hroo.2021.07.003
pii: S2666-5018(21)00120-3
pmc: PMC8369290
doi:
Types de publication
Journal Article
Langues
eng
Pagination
405-411Informations de copyright
© 2021 Heart Rhythm Society. Published by Elsevier Inc.
Références
Circ Arrhythm Electrophysiol. 2014 Oct;7(5):785-92
pubmed: 25136077
N Engl J Med. 2012 Dec 13;367(24):2275-83
pubmed: 23131066
N Engl J Med. 1996 Dec 26;335(26):1933-40
pubmed: 8960472
J Am Coll Cardiol. 2008 Apr 8;51(14):1357-65
pubmed: 18387436
Heart Rhythm. 2020 Jan;17(1):e220-e228
pubmed: 31103461
Heart Rhythm. 2016 Feb;13(2):e50-86
pubmed: 26607062
JAMA. 2013 May 8;309(18):1903-11
pubmed: 23652522
N Engl J Med. 2005 Jan 20;352(3):225-37
pubmed: 15659722
N Engl J Med. 2002 Mar 21;346(12):877-83
pubmed: 11907286
Circulation. 2004 Oct 26;110(17):2591-6
pubmed: 15492306
Circulation. 2001 Aug 14;104(7):796-801
pubmed: 11502705
N Engl J Med. 2008 Sep 4;359(10):1009-17
pubmed: 18768944
Pacing Clin Electrophysiol. 1993 Mar;16(3 Pt 2):535-9
pubmed: 7681953
J Am Coll Cardiol. 2011 Feb 1;57(5):556-62
pubmed: 21272746
J Am Coll Cardiol. 2013 Mar 26;61(12):1318-68
pubmed: 23453819
J Am Coll Cardiol. 2008 Aug 12;52(7):541-50
pubmed: 18687248
Heart Rhythm. 2021 Mar;18(3):399-403
pubmed: 33232811