Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[
Animals
Dependovirus
Disease Models, Animal
Disease Progression
Dopaminergic Neurons
/ pathology
Fluorine Radioisotopes
Male
Motor Activity
Parkinson Disease
/ diagnostic imaging
Phosphorylation
Positron-Emission Tomography
Protein Aggregates
Rats, Sprague-Dawley
Synucleinopathies
/ diagnostic imaging
Tyrosine
alpha-Synuclein
/ metabolism
A53T-AAV asynuclein rat model
Behaviors
Brain imaging
Dopaminergic degeneration
FMT PET imaging
Parkinson''s disease
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
19
11
2019
revised:
15
07
2021
accepted:
15
07
2021
pubmed:
26
8
2021
medline:
27
1
2022
entrez:
25
8
2021
Statut:
ppublish
Résumé
With the emergence of disease-modifying therapies for Parkinson's disease, reliable longitudinal markers are needed to quantify pathology and demonstrate disease progression. We developed the A53T-AAV rat model of synucleinopathy by combining longitudinal measures over 12 weeks. We first characterized the progression of the motor and dopaminergic deficits. Then, we monitored the disease progression using the [
Identifiants
pubmed: 34433125
pii: S0197-4580(21)00238-4
doi: 10.1016/j.neurobiolaging.2021.07.012
pii:
doi:
Substances chimiques
Fluorine Radioisotopes
0
Protein Aggregates
0
alpha-Synuclein
0
Tyrosine
42HK56048U
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-152Informations de copyright
Copyright © 2021. Published by Elsevier Inc.