Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.

Aged Animals Atrial Fibrillation / drug therapy Cells, Cultured Female Fibrosis Humans Male Mesalamine / pharmacology Mice Mice, Inbred C57BL Middle Aged Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors Myocardium / metabolism Myofibroblasts / drug effects Osteopontin / metabolism Protein Kinase Inhibitors / pharmacology Protein Serine-Threonine Kinases / genetics
atrial fibrillation fibroblasts fibrosis mesalamine osteopontin

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
10 2021
Historique:
pubmed: 27 8 2021
medline: 11 1 2022
entrez: 26 8 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/CIRCRESAHA.121.319425 PMID: 34433292 PMC: PMC8487716
pubmed: 34433292
doi: 10.1161/CIRCRESAHA.121.319425
pmc: PMC8487716
doi:

Substances chimiques

Protein Kinase Inhibitors 0
Osteopontin 106441-73-0
Mesalamine 4Q81I59GXC
PLK2 protein, human EC 2.7.11.-
Protein Serine-Threonine Kinases EC 2.7.11.1
Mitogen-Activated Protein Kinase 1 EC 2.7.11.24
Mitogen-Activated Protein Kinase 3 EC 2.7.11.24

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

804-820

Subventions

Organisme : British Heart Foundation
ID : AA/18/2/34218
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/16/3/32406
Pays : United Kingdom

Références

Cardiovasc Res. 2017 Dec 1;113(14):1743-1752
pubmed: 29016722
J Leukoc Biol. 2005 Jul;78(1):289-300
pubmed: 15857938
Mol Cell Proteomics. 2013 Apr;12(4):956-78
pubmed: 23345538
Cardiovasc Res. 2008 Dec 1;80(3):396-406
pubmed: 18689792
J Am Coll Cardiol. 2015 Aug 25;66(8):943-59
pubmed: 26293766
J Biol Chem. 2012 May 4;287(19):15923-34
pubmed: 22427657
Europace. 2021 Jun 7;23(6):958-969
pubmed: 33462602
Hypertension. 1999 Feb;33(2):663-70
pubmed: 10024324
Circ Res. 2013 Oct 25;113(10):1138-47
pubmed: 24006456
J Am Coll Cardiol. 2016 Oct 25;68(17):1881-1894
pubmed: 27765191
J Am Heart Assoc. 2017 Oct 24;6(10):
pubmed: 29066438
J Biol Chem. 2001 Jul 27;276(30):28261-7
pubmed: 11375993
Circulation. 1999 Jul 6;100(1):87-95
pubmed: 10393686
Blood. 2006 Jan 1;107(1):250-6
pubmed: 16160013
J Am Heart Assoc. 2020 Feb 4;9(3):e013518
pubmed: 32000579
Chem Biol Interact. 2018 Jun 1;289:109-118
pubmed: 29738702
Mol Cell Biol. 2003 Oct;23(19):6936-43
pubmed: 12972611
Circ Res. 2018 Mar 2;122(5):752-773
pubmed: 29496798
Cells. 2021 Mar 11;10(3):
pubmed: 33799608
Hypertension. 2004 Dec;44(6):826-31
pubmed: 15534078
Circ Arrhythm Electrophysiol. 2008 Apr;1(1):62-73
pubmed: 19808395
J Cardiovasc Pharmacol. 2011 Apr;57(4):376-9
pubmed: 21297493
Physiol Rev. 2012 Apr;92(2):635-88
pubmed: 22535894
Cytokine Growth Factor Rev. 2006 Dec;17(6):463-74
pubmed: 17113338
J Inflamm Res. 2010;3:75-97
pubmed: 22096359
Circ Res. 2008 Feb 15;102(3):319-27
pubmed: 18079410
Nat Rev Cardiol. 2017 Aug;14(8):484-491
pubmed: 28436487
Heart Rhythm. 2015 Sep;12(9):1945-55
pubmed: 26001508
Eur Heart J. 2006 Jan;27(2):136-49
pubmed: 16278230
Cell. 1999 Oct 29;99(3):247-57
pubmed: 10555141
Circ Res. 2017 Jan 6;120(1):120-132
pubmed: 27799254
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
FEBS Open Bio. 2020 Jul;10(7):1210-1218
pubmed: 32421922
Adv Med Sci. 2018 Mar;63(1):160-166
pubmed: 29120858
Ann Hematol. 2011 Sep;90(9):1037-45
pubmed: 21340720
Am J Hypertens. 2004 Feb;17(2):188-93
pubmed: 14751663
Respir Res. 2012 Aug 31;13:74
pubmed: 22938014
Oncogene. 2002 Aug 12;21(35):5483-95
pubmed: 12154409
Life Sci. 2020 Mar 15;245:117328
pubmed: 31954162
J Biol Chem. 2009 Jan 30;284(5):2598-2602
pubmed: 19004816
Heart Rhythm. 2010 Dec;7(12):1862-9
pubmed: 20728579
Physiol Rep. 2016 Feb;4(2):
pubmed: 26811054
Circ Res. 2001 May 25;88(10):1080-7
pubmed: 11375279
J Am Coll Cardiol. 2020 Apr 14;75(14):1689-1713
pubmed: 32273035
Europace. 2018 Jan 1;20(1):33-42
pubmed: 28444307
J Cell Physiol. 2004 Mar;198(3):399-407
pubmed: 14755545
Cardiovasc Res. 2016 Apr 1;109(4):527-41
pubmed: 26786160
Naunyn Schmiedebergs Arch Pharmacol. 2021 Mar;394(3):533-543
pubmed: 33064167
Cardiovasc Pathol. 2010 Mar-Apr;19(2):102-11
pubmed: 19211267
J Am Coll Cardiol. 2005 Jan 18;45(2):285-92
pubmed: 15653029
PLoS One. 2011;6(10):e26064
pubmed: 22016813
Free Radic Biol Med. 2014 Aug;73:270-7
pubmed: 24887096
Europace. 2018 Jun 1;20(6):956-962
pubmed: 28605524
J Cardiovasc Electrophysiol. 2014 Jun;25(6):609-16
pubmed: 24400815
Cardiovasc Res. 2013 Jul 1;99(1):111-20
pubmed: 23619422
Europace. 2016 Oct;18(10):1455-1490
pubmed: 27402624
Int J Cardiol Heart Vasc. 2018 Sep 13;21:11-15
pubmed: 30225340
Circ J. 2015;79(3):495-502
pubmed: 25746525

Auteurs

Stephan R Künzel (SR)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
Department of Dermatology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K.).

Maximilian Hoffmann (M)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
ORCID: 0000-0003-3427-8409

Silvio Weber (S)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Karolina Künzel (K)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Susanne Kämmerer (S)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Mario Günscht (M)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
ORCID: 0000-0003-1686-6442

Erik Klapproth (E)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Johanna S E Rausch (JSE)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Mirna S Sadek (MS)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Tomasz Kolanowski (T)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
ORCID: 0000-0003-3898-8272

Stefanie Meyer-Roxlau (S)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).

Christopher Piorkowski (C)

Department of Rhythmology (C.P., M.W.), Clinic for Internal Medicine and Cardiology, Heart Center Dresden GmbH, Dresden, Technische Universität Dresden.
ORCID: 0000-0003-1103-7944

Sems M Tugtekin (SM)

Department of Cardiac Surgery (S.M.T.), Clinic for Internal Medicine and Cardiology, Heart Center Dresden GmbH, Dresden, Technische Universität Dresden.

Stefan Rose-John (S)

Unit for Degradomics of the Protease Web, Institute of Biochemistry, University of Kiel (S.R.-J.).

Xiaoke Yin (X)

The James Black Centre, King's College, University of London (X.Y., M.M.).
ORCID: 0000-0002-5172-0935

Manuel Mayr (M)

The James Black Centre, King's College, University of London (X.Y., M.M.).
Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden (M.M.).
ORCID: 0000-0002-0597-829X

Jan Dominik Kuhlmann (JD)

Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden (J.D.K., P.W.).
German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg (J.D.K., P.W.).
National Center for Tumor Diseases (NCT), Partner Site Dresden (J.D.K., P.W., K.G.).

Pauline Wimberger (P)

Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden (J.D.K., P.W.).
German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg (J.D.K., P.W.).
National Center for Tumor Diseases (NCT), Partner Site Dresden (J.D.K., P.W., K.G.).
ORCID: 0000-0002-7380-577X

Konrad Grützmann (K)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
National Center for Tumor Diseases (NCT), Partner Site Dresden (J.D.K., P.W., K.G.).

Natalie Herzog (N)

Brandenburg University of Technology, Senftenberg (N.H., J.-H.K.).

Jan-Heiner Küpper (JH)

Brandenburg University of Technology, Senftenberg (N.H., J.-H.K.).

Molly O'Reilly (M)

Institute of Cardiovascular Sciences, University of Birmingham (M.O., S.N.K., L.C.S.).
ORCID: 0000-0003-1936-5838

S Nashitha Kabir (SN)

Institute of Cardiovascular Sciences, University of Birmingham (M.O., S.N.K., L.C.S.).

Laura C Sommerfeld (LC)

Institute of Cardiovascular Sciences, University of Birmingham (M.O., S.N.K., L.C.S.).
University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center Hamburg (L.F., L.C.S.).
ORCID: 0000-0001-9837-8770

Kaomei Guan (K)

ORCID: 0000-0002-0753-3083

Ben Wielockx (B)

Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden (B.W.).
ORCID: 0000-0002-4923-2596

Larissa Fabritz (L)

Department of Cardiology, University Hospitals Birmingham (L.F.).
University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center Hamburg (L.F., L.C.S.).
ORCID: 0000-0002-9241-1733

Stanley Nattel (S)

Department of Medicine, Montreal Heart Institute and Université de Montréal, Quebec, Canada (S.N., D.D.).
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen (S.N., D.D.).
IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université (S.N.).
ORCID: 0000-0002-5565-3311

Ursula Ravens (U)

Institut für Experimentelle Kardiovaskuläre Medizin, Universitäts Herzzentrum, Freiburg Bad Krotzingen, Freiburg im Breisgau (U.R.).

Dobromir Dobrev (D)

Department of Medicine, Montreal Heart Institute and Université de Montréal, Quebec, Canada (S.N., D.D.).
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen (S.N., D.D.).
Department of Molecular Physiology and Biophysics, Baylor College of Medicine (D.D.).
ORCID: 0000-0002-4612-117X

Michael Wagner (M)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
Department of Rhythmology (C.P., M.W.), Clinic for Internal Medicine and Cardiology, Heart Center Dresden GmbH, Dresden, Technische Universität Dresden.
ORCID: 0000-0002-6300-5752

Ali El-Armouche (A)

Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden (S.R.K., M.H., S.W., K.K., S.K., M.G., E.K., J.S.E.R., M.S.S., T.K., S.M.-R., K.G., M.W., A.E.-A.).
ORCID: 0000-0003-2514-9429

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Eucaryotes › Animaux › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Cellules › Cellules cultivées › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Salicylates › Acides amino-salicyliques › Mésalazine › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 1 › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 3 › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Myofibroblastes › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Ostéopontine › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Diminished PLK2 Induces Cardiac Fibrosis and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Diminished PLK2 Induces Cardiac Fibrosis and...