Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
received:
19
08
2020
accepted:
05
08
2021
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
25
9
2021
Statut:
epublish
Résumé
Radiological examination of the brain is a critical determinant of stroke care pathways. Accessible neuroimaging is essential to detect the presence of intracerebral hemorrhage (ICH). Conventional magnetic resonance imaging (MRI) operates at high magnetic field strength (1.5-3 T), which requires an access-controlled environment, rendering MRI often inaccessible. We demonstrate the use of a low-field MRI (0.064 T) for ICH evaluation. Patients were imaged using conventional neuroimaging (non-contrast computerized tomography (CT) or 1.5/3 T MRI) and portable MRI (pMRI) at Yale New Haven Hospital from July 2018 to November 2020. Two board-certified neuroradiologists evaluated a total of 144 pMRI examinations (56 ICH, 48 acute ischemic stroke, 40 healthy controls) and one ICH imaging core lab researcher reviewed the cases of disagreement. Raters correctly detected ICH in 45 of 56 cases (80.4% sensitivity, 95%CI: [0.68-0.90]). Blood-negative cases were correctly identified in 85 of 88 cases (96.6% specificity, 95%CI: [0.90-0.99]). Manually segmented hematoma volumes and ABC/2 estimated volumes on pMRI correlate with conventional imaging volumes (ICC = 0.955, p = 1.69e-30 and ICC = 0.875, p = 1.66e-8, respectively). Hematoma volumes measured on pMRI correlate with NIH stroke scale (NIHSS) and clinical outcome (mRS) at discharge for manual and ABC/2 volumes. Low-field pMRI may be useful in bringing advanced MRI technology to resource-limited settings.
Identifiants
pubmed: 34433813
doi: 10.1038/s41467-021-25441-6
pii: 10.1038/s41467-021-25441-6
pmc: PMC8387402
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5119Subventions
Organisme : NINR NIH HHS
ID : R01 NR018335
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS107136
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NINDS NIH HHS
ID : R03 NS112859
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS107215
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS106513
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110721
Pays : United States
Informations de copyright
© 2021. The Author(s).
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