Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment of
Nanoemulsion
gelatin
miconazole
topical delivery system
Journal
Designed monomers and polymers
ISSN: 1385-772X
Titre abrégé: Des Monomers Polym
Pays: England
ID NLM: 101239706
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
27
8
2021
Statut:
epublish
Résumé
In the current research, attempt is made to fabricate a nanoemulsion (NE) containing an antifungal agent. The prepared formulation has been expected to enhance skin penetration. It is also studied for in vitro drug release and toxicity assessment. Spontaneous titration method was used for preparation of NE. Prepared NE were characterized for their charge, size, morphology, rheological behaviour, drug release profile, skin permeability. The drug permeation and skin irritation were investigated. The in vitro antifungal activity was inspected using the well agar diffusion method. Miconazole NE showed good penetration in the skin as compared to marketed products. SEM showed semispherical shapes of the droplets. Zeta potential and zeta sizer showed that size was in nano ranges having positive charge.
Identifiants
pubmed: 34434070
doi: 10.1080/15685551.2021.1965724
pii: 1965724
pmc: PMC8382019
doi:
Types de publication
Journal Article
Langues
eng
Pagination
240-258Informations de copyright
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
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