Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
12
2020
revised:
09
07
2021
accepted:
23
07
2021
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
20
1
2022
Statut:
epublish
Résumé
Recent studies reported the association between increased risk of nonmelanoma skin cancers (NMSCs) and the use of hydrochlorothiazide (HCTZ), one of the most commonly prescribed diuretic, antihypertensive drug, over the world. Although HCTZ is known to be photosensitizing, the mechanisms involved in its potential prophotocarcinogenic effects remain unclear. Under acute exposure, therapeutically relevant concentrations of HCTZ (70, 140, and 370 ng/mL) amplified UVA-induced double-strand breaks, oxidative DNA, and protein damage in HaCaT human keratinocytes, and this effect was associated to a defective activity of the DNA repair enzyme, OGG1. Oxidative damage to DNA, but not that to proteins, was reversible within few hours. After chronic, combined exposure to HCTZ (70 ng/mL) and UVA (10 J/cm
Identifiants
pubmed: 34434485
doi: 10.1155/2021/6655542
pmc: PMC8382532
doi:
Substances chimiques
Hydrochlorothiazide
0J48LPH2TH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6655542Informations de copyright
Copyright © 2021 Elisabetta Bigagli et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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