Congenital Heart Disease: An Immunological Perspective.
congenital heart disease
immune response
inflammation
models of CHD
primary immunodeficiency
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
13
07
2021
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Congenital heart disease (CHD) poses a significant global health and economic burden-despite advances in treating CHD reducing the mortality risk, globally CHD accounts for approximately 300,000 deaths yearly. Children with CHD experience both acute and chronic cardiac complications, and though treatment options have improved, some remain extremely invasive. A challenge in addressing these morbidity and mortality risks is that little is known regarding the cause of many CHDs and current evidence suggests a multifactorial etiology. Some studies implicate an immune contribution to CHD development; however, the role of the immune system is not well-understood. Defining the role of the immune and inflammatory responses in CHD therefore holds promise in elucidating mechanisms underlying these disorders and improving upon current diagnostic and treatment options. In this review, we address the current knowledge coinciding CHDs with immune and inflammatory associations, emphasizing conditions where this understanding would provide clinical benefit, and challenges in studying these mechanisms.
Identifiants
pubmed: 34434978
doi: 10.3389/fcvm.2021.701375
pmc: PMC8380780
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
701375Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140305
Pays : United States
Informations de copyright
Copyright © 2021 Singampalli, Jui, Shani, Ning, Connell, Birla, Bollyky, Caldarone, Keswani and Grande-Allen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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