Interaction between Preterm White Matter Injury and Childhood Thalamic Growth.
Brain
/ growth & development
Brain Injuries
/ pathology
Child
Child Development
/ physiology
Diffusion Tensor Imaging
/ methods
Gestational Age
Humans
Infant
Infant, Extremely Premature
/ growth & development
Infant, Newborn
Magnetic Resonance Imaging
/ methods
Male
White Matter
/ growth & development
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
09
08
2021
received:
05
02
2021
accepted:
15
08
2021
pubmed:
27
8
2021
medline:
15
12
2021
entrez:
26
8
2021
Statut:
ppublish
Résumé
The purpose of this study was to determine how preterm white matter injury (WMI) and long-term thalamic growth interact to predict 8-year neurodevelopmental outcomes. A prospective cohort of 114 children born at 24 to 32 weeks' gestational age (GA) underwent structural and diffusion tensor magnetic resonance imaging early in life (median 32 weeks), at term-equivalent age and at 8 years. Manual segmentation of neonatal WMI was performed on T1-weighted images and thalamic volumes were obtained using the MAGeT brain segmentation pipeline. Cognitive, motor, and visual-motor outcomes were evaluated at 8 years of age. Multivariable regression was used to examine the relationship among neonatal WMI volume, school-age thalamic volume, and neurodevelopmental outcomes. School-age thalamic volumes were predicted by neonatal thalamic growth rate, GA, sex, and neonatal WMI volume (p < 0.0001). After accounting for total cerebral volume, WMI volume remained associated with school-age thalamic volume (β = -0.31, p = 0.005). In thalamocortical tracts, fractional anisotropy (FA) at term-equivalent age interacted with early WMI volume to predict school-age thalamic volumes (all p < 0.02). School-age thalamic volumes and neonatal WMI interacted to predict full-scale IQ (p = 0.002) and adverse motor scores among those with significant WMI (p = 0.01). Visual-motor scores were predicted by thalamic volumes (p = 0.04). In very preterm-born children, neonatal thalamic growth and WMI volume predict school-age thalamic volumes. The emergence at term of an interaction between FA and WMI to impact school-age thalamic volume indicates dysmaturation as a mechanism of thalamic growth failure. Cognition is predicted by the interaction of WMI and thalamic growth, highlighting the need to consider multiple dimensions of brain injury in these children. ANN NEUROL 2021;90:584-594.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
584-594Subventions
Organisme : CIHR
ID : MOP-79262
Pays : Canada
Organisme : CIHR
ID : MOP-86489
Pays : Canada
Organisme : Ted Arison Family Foundation
Organisme : Bloorview Children's Hospital Chair in Paediatric Neuroscience
Organisme : Kids Brain Health Network
Organisme : CIHR
ID : MOP-79262
Pays : Canada
Organisme : CIHR
ID : MOP-86489
Pays : Canada
Informations de copyright
© 2021 American Neurological Association.
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