Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
pubmed:
27
8
2021
medline:
15
12
2021
entrez:
26
8
2021
Statut:
ppublish
Résumé
The current pharmaceutical market lacks therapeutic agents designed to modulate behavioral disturbances associated with dementia. To address this unmet medical need, we designed multifunctional ligands characterized by a nanomolar affinity for clinically relevant targets that are associated with the disease pathology, namely, the 5-HT
Identifiants
pubmed: 34436892
doi: 10.1021/acs.jmedchem.1c00497
pmc: PMC8436213
doi:
Substances chimiques
Antidepressive Agents
0
Central Nervous System Agents
0
Sulfonamides
0
Sulfones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12603-12629Références
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