Long-Term Follow-Up of Renal Function in Children after Liver Transplantation-A Single Center Retrospective Study.
chronic kidney disease
immunosuppression
liver transplantation
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
25 Jul 2021
25 Jul 2021
Historique:
received:
31
05
2021
revised:
21
07
2021
accepted:
23
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of screening for renal tubular defects and blood concentrations of basic immunosuppressive drug-tacrolimus. CKD was diagnosed in 3% of children at 12 years after LT. The maintaining of tacrolimus concentrations >4 ng/mL in long-term observation was associated with a significant increase of microalbuminuria. The presence of microalbuminuria, regarded as a risk factor of CKD, confirmed the necessity of regular comprehensive assessment of patients in long-term follow-up.
Identifiants
pubmed: 34438524
pii: children8080633
doi: 10.3390/children8080633
pmc: PMC8391198
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Statutory Grant from the Polish Ministry of Science and Higher Education
ID : s183/2019
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