All the Pups We Cannot See: Cannibalism Masks Perinatal Death in Laboratory Mouse Breeding but Infanticide Is Rare.
3Rs principle
asynchrony breeding
cage inspection
cannibalistic behaviour
husbandry practices
mouse welfare
neonatal mortality
pup-counting method
social environment
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
06 Aug 2021
06 Aug 2021
Historique:
received:
26
06
2021
revised:
29
07
2021
accepted:
03
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Perinatal mortality is a major issue in laboratory mouse breeding. We compared a counting method using daily checks (DAILY_CHECK) with a method combining daily checks with detailed video analyses to detect cannibalisms (VIDEO_TRACK) for estimating the number of C57BL/6 pups that were born, that died and that were weaned in 193 litters from trios with (TRIO-OVERLAP) or without (TRIO-NO_OVERLAP) the presence of another litter. Linear mixed models were used at litter level. To understand whether cannibalism was associated with active killing (infanticide), we analysed VIDEO_TRACK recordings of 109 litters from TRIO-OVERLAP, TRIO-NO_OVERLAP or SOLO (single dams). We used Kaplan-Meier method and logistic regression at pup level. For DAILY_CHECK, the mean litter size was 35% smaller than for VIDEO_TRACK (
Identifiants
pubmed: 34438784
pii: ani11082327
doi: 10.3390/ani11082327
pmc: PMC8388445
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Regional Development Fund
ID : POCI-01-0145-FEDER-016591
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/CVT-WEL/1202/2014
Références
Lab Anim (NY). 2009 Jan;38(1):24-34
pubmed: 19112447
Lab Anim (NY). 2006 Jan;35(1):15
pubmed: 16382226
J Am Assoc Lab Anim Sci. 2016;55(4):387-99
pubmed: 27423144
Behav Processes. 1994 Apr;31(2-3):285-91
pubmed: 24924940
Philos Trans R Soc Lond B Biol Sci. 2019 Sep 2;374(1780):20180075
pubmed: 31303157
Behav Genet. 1993 Nov;23(6):525-31
pubmed: 8129694
PLoS One. 2016 May 05;11(5):e0154966
pubmed: 27148872
Acta Vet Scand. 2013 Nov 20;55:83
pubmed: 24256697
PLoS One. 2016 Aug 30;11(8):e0161238
pubmed: 27575720
PLoS One. 2013 Sep 11;8(9):e74153
pubmed: 24040193
Physiol Behav. 2002 Apr 1;75(4):551-5
pubmed: 12062319
Reprod Suppl. 2001;58:263-6
pubmed: 11980195
Lab Anim. 2019 Feb;53(1):53-62
pubmed: 29788793
Curr Protoc Mouse Biol. 2012 Jun;2:145-165
pubmed: 22822473
J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):190-193
pubmed: 28315650
Am Nat. 2019 Jan;193(1):106-124
pubmed: 30624110
Lab Anim. 2001 Jan;35(1):58-73
pubmed: 11201289
Neuropharmacology. 2019 Sep 15;156:107451
pubmed: 30502376
Lab Anim. 2016 Oct;50(5):370-8
pubmed: 26568578
PLoS One. 2020 Aug 12;15(8):e0236290
pubmed: 32785214
Evolution. 2008 Mar;62(3):612-21
pubmed: 17983462
Behav Processes. 1993 Aug;30(1):61-73
pubmed: 24896472
Physiol Behav. 1985 Dec;35(6):843-9
pubmed: 3912779
PLoS One. 2015 May 28;10(5):e0127875
pubmed: 26020792
Proc Biol Sci. 2016 May 11;283(1830):
pubmed: 27170710
Lab Anim. 2002 Apr;36(2):188-92
pubmed: 11943084
Reprod Domest Anim. 2013 Apr;48(2):292-6
pubmed: 22809230