The Role of LncRNAs in Uveal Melanoma.
cancer
diagnosis
epigenetics
lncRNA
noncoding RNA
therapy
uveal melanoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Aug 2021
11 Aug 2021
Historique:
received:
29
06
2021
revised:
06
08
2021
accepted:
06
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Uveal melanoma (UM) is an intraocular cancer tumor with high metastatic risk. It is considered a rare disease, but 90% of affected patients die within 15 years. Non-coding elements (ncRNAs) such as long non-coding RNAs (lncRNAs) have a crucial role in cellular homeostasis maintenance, taking part in many critical cellular pathways. Their deregulation, therefore, contributes to the induction of cancer and neurodegenerative and metabolic diseases. In cancer, lncRNAs are implicated in apoptosis evasion, proliferation, invasion, drug resistance, and other roles because they affect tumor suppressor genes and oncogenes. For these reasons, lncRNAs are promising targets in personalized medicine and can be used as biomarkers for diseases including UM.
Identifiants
pubmed: 34439196
pii: cancers13164041
doi: 10.3390/cancers13164041
pmc: PMC8392202
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2016-78454-C2-2-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2014-56763-R
Organisme : Ludwig Center at Harvard
ID : N/A
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : BES-2017-082521
Organisme : NCI NIH HHS
ID : R35 CA232105
Pays : United States
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2017-87305-R
Organisme : NCI Outstanding Investigator Award
ID : R35CA232105
Organisme : Comunidad de Madrid
ID : S2013/MIT-2850
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SEV-2016-0686-17-3
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