Left Ventricular SGLT1 Protein Expression Correlates with the Extent of Myocardial Nitro-Oxidative Stress in Rats with Pressure and Volume Overload-Induced Heart Failure.
NADPH oxidase 4
heart failure
myocardial nitro-oxidative stress
pressure overload
sodium-glucose cotransporter 1
sodium-glucose cotransporter 2 inhibitor
volume overload
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
17
06
2021
revised:
22
07
2021
accepted:
23
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Myocardial sodium-glucose cotransporter 1 (SGLT1) has been shown to be upregulated in humans with heart failure (HF) with or without diabetes. In vitro studies have linked SGLT1 to increased nitro-oxidative stress in cardiomyocytes. We aimed to assess the relation between left ventricular (LV) SGLT1 expression and the extent of nitro-oxidative stress in two non-diabetic rat models of chronic heart failure (HF) evoked by either pressure (TAC,
Identifiants
pubmed: 34439438
pii: antiox10081190
doi: 10.3390/antiox10081190
pmc: PMC8388925
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research, Development and Innovation Fund of Hungary
ID : NVKP_16-1-2016-0017
Organisme : Ministry for Innovation and Technology in Hungary
ID : Thematic Excellence Programme (2020-4.1.1.-TKP2020)
Organisme : National Research, Development and Innovation Office (NKFIH) of Hungary
ID : K134939
Organisme : Semmelweis University
ID : EFOP-3.6.3-VEKOP-16-2017-00009
Organisme : Ministry of Human Capacities
ID : ÚNKP-20-4-II-SE-20
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