Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.
Animals
Apoptosis
CCAAT-Enhancer-Binding Protein-delta
/ biosynthesis
Cell Line, Tumor
Cell Proliferation
DNA-Binding Proteins
/ metabolism
Data Mining
Disease Progression
Gene Expression Regulation
Humans
Mice
Neoplasm Metastasis
Neoplasm Transplantation
Pancreatic Neoplasms
/ metabolism
Platelet Membrane Glycoproteins
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Tissue Array Analysis
Trans-Activators
/ metabolism
Tumor Microenvironment
CCAAT/enhancer-binding protein delta
CEBPD
PDAC
extravasation
metastasis
pancreatic cancer
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
22 07 2021
22 07 2021
Historique:
received:
23
06
2021
revised:
16
07
2021
accepted:
19
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
26
10
2021
Statut:
epublish
Résumé
CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells. Loss of nuclear C/EBPδ in PDAC cells is associated with decreased patient survival and pro-tumorigenic properties in vitro. Interestingly however, next to C/EBPδ expression in tumor cells, C/EBPδ is also expressed by cells constituting the tumor microenvironment and by cells comprising the organs and parenchyma. However, the functional relevance of systemic C/EBPδ in carcinogenesis remains elusive. Here, we consequently assessed the potential importance of C/EBPδ in somatic tissues by utilizing an orthotopic pancreatic cancer model. In doing so, we show that genetic ablation of C/EBPδ does not significantly affect primary tumor growth but has a strong impact on metastases; wildtype mice developed metastases at multiple sites, whilst this was not the case in C/EBPδ
Identifiants
pubmed: 34439745
pii: biom11081079
doi: 10.3390/biom11081079
pmc: PMC8391339
pii:
doi:
Substances chimiques
CEBPD protein, human
0
Cebpd protein, rat
0
DNA-Binding Proteins
0
Platelet Membrane Glycoproteins
0
Receptors, G-Protein-Coupled
0
Trans-Activators
0
platelet activating factor receptor
0
CCAAT-Enhancer-Binding Protein-delta
142662-43-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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