Exosome microRNAs in Amyotrophic Lateral Sclerosis: A Pilot Study.
amyotrophic lateral sclerosis
biomarkers
exosome
miRNA
serum
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 08 2021
16 08 2021
Historique:
received:
13
07
2021
revised:
11
08
2021
accepted:
13
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The pathogenesis of amyotrophic lateral sclerosis (ALS), a lethal neurodegenerative disease, remains undisclosed. Mutations in ALS related genes have been identified, albeit the majority of cases are unmutated. Clinical pathology of ALS suggests a prion-like cell-to-cell diffusion of the disease possibly mediated by exosomes, small endocytic vesicles involved in the propagation of RNA molecules and proteins. In this pilot study, we focused on exosomal microRNAs (miRNAs), key regulators of many signaling pathways. We analyzed serum-derived exosomes from ALS patients in comparison with healthy donors. Exosomes were obtained by a commercial kit. Purification of miRNAs was performed using spin column chromatography and RNA was reverse transcribed into cDNA. All samples were run on the miRCURY LNA
Identifiants
pubmed: 34439885
pii: biom11081220
doi: 10.3390/biom11081220
pmc: PMC8394507
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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