Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics.
atypical antipsychotics
diet
microbiome
pharmacogenetics
pharmacogenomics
psychosis
severe mental disorders
typical antipsychotics
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
22
06
2021
revised:
14
07
2021
accepted:
21
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
The gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this work we characterized the composition of the gut microbiota in 38 patients with schizophrenia (SCZ) and 20 healthy controls (HC), and tested if SCZ patients with different response to antipsychotics (18 patients with treatment resistant schizophrenia (TRS), and 20 responders (R)) had specific patterns of gut microbiota composition associated with different response to antipsychotics. Moreover, we also tested if patients treated with typical antipsychotics (n = 20) presented significant differences when compared to patients treated with atypical antipsychotics (n = 31). Our findings showed the presence of distinct composition of gut microbiota in SCZ versus HC, with several bacteria at the different taxonomic levels only present in either one group or the other. Similar findings were observed also depending on treatment response and exposure to diverse classes of antipsychotics. Our results suggest that composition of gut microbiota could constitute a biosignatures of SCZ and TRS.
Identifiants
pubmed: 34440078
pii: biomedicines9080875
doi: 10.3390/biomedicines9080875
pmc: PMC8389684
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Lancet. 2016 Jul 2;388(10039):86-97
pubmed: 26777917
BMC Psychiatry. 2017 Jan 13;17(1):12
pubmed: 28086761
Schizophr Bull. 2013 Nov;39(6):1169-72
pubmed: 24045038
Sci Rep. 2019 Feb 4;9(1):1177
pubmed: 30718836
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
BMJ Open. 2020 Jan 26;10(1):e032513
pubmed: 31988227
PLoS Med. 2005 May;2(5):e141
pubmed: 15916472
J Child Psychol Psychiatry. 2020 Mar;61(3):353-371
pubmed: 31773737
Nutrients. 2021 Mar 31;13(4):
pubmed: 33807241
Nature. 2019 Jun;570(7762):462-467
pubmed: 31158845
Sci Rep. 2019 Oct 16;9(1):14840
pubmed: 31619731
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Front Neurosci. 2015 Oct 21;9:372
pubmed: 26539073
PLoS One. 2015 Jul 28;10(7):e0134234
pubmed: 26218067
J Psychiatr Res. 2020 Nov;130:48-56
pubmed: 32781373
Mol Psychiatry. 2016 Jun;21(6):738-48
pubmed: 27090305
Curr Drug Metab. 2018;19(8):688-694
pubmed: 29283065
Front Psychiatry. 2021 Jan 12;11:585769
pubmed: 33510657
Schizophr Res. 2019 Feb;204:23-29
pubmed: 30268819
PLoS One. 2018 Apr 12;13(4):e0195687
pubmed: 29649252
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Bull Exp Biol Med. 2017 Apr;162(6):734-737
pubmed: 28429209
JAMA Psychiatry. 2015 Dec;72(12):1172-81
pubmed: 26509694
Acta Neuropsychiatr. 2020 Feb;32(1):32-42
pubmed: 31753055
Behav Brain Res. 2021 Jan 1;396:112886
pubmed: 32890599
Br J Psychiatry. 2011 Mar;198(3):173-5
pubmed: 21357874
Neurosci Biobehav Rev. 2020 Jan;108:712-731
pubmed: 31821833
Cell. 2020 Jun 25;181(7):1661-1679.e22
pubmed: 32526207
BJPsych Bull. 2019 Feb;43(1):8-16
pubmed: 30261942
Can J Psychiatry. 2017 Nov;62(11):772-777
pubmed: 28655284
Am J Psychiatry. 2017 Mar 1;174(3):216-229
pubmed: 27919182
Schizophr Bull. 2018 Oct 17;44(6):1195-1203
pubmed: 29762765
Psychol Med. 2017 Aug;47(11):1981-1989
pubmed: 28395674
Biomedicines. 2020 Aug 27;8(9):
pubmed: 32867257
Schizophr Res. 2021 Aug;234:4-23
pubmed: 32336581
Am J Psychiatry. 2004 Feb;161(2 Suppl):1-56
pubmed: 15000267
Mol Psychiatry. 2020 Nov;25(11):2905-2918
pubmed: 31391545
Int J Mol Sci. 2018 Sep 27;19(10):
pubmed: 30261687
Psychiatry Res Neuroimaging. 2018 Dec 30;282:47-54
pubmed: 30412902
NPJ Schizophr. 2020 Jan 7;6(1):1
pubmed: 31911624
Int J Neuropsychopharmacol. 2021 Mar 17;24(3):216-220
pubmed: 33693884
Front Cell Infect Microbiol. 2020 May 19;10:223
pubmed: 32509596
Sci Rep. 2021 May 7;11(1):9743
pubmed: 33963227
Br Med J (Clin Res Ed). 1987 Sep 19;295(6600):681-2
pubmed: 3117295
Psychol Med. 2016 Nov;46(15):3231-3240
pubmed: 27605254
Crit Rev Food Sci Nutr. 2019;59(4):537-545
pubmed: 28910544
Psychiatr Genet. 2019 Oct;29(5):160-169
pubmed: 31464997
Gut Microbes. 2012 Jul-Aug;3(4):374-82
pubmed: 22825455
Am J Psychiatry. 1994 Dec;151(12):1744-52
pubmed: 7977880
Arch Gen Psychiatry. 1988 Sep;45(9):789-96
pubmed: 3046553