The Genetics of Myelodysplastic Syndromes: Clinical Relevance.
disease classification
gene mutations
myelodysplastic syndrome
prognosis
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
received:
20
05
2021
revised:
05
07
2021
accepted:
22
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Myelodysplastic syndromes (MDS) are a clonal disease arising from hematopoietic stem cells, that are characterized by ineffective hematopoiesis (leading to peripheral blood cytopenia) and by an increased risk of evolution into acute myeloid leukemia. MDS are driven by a complex combination of genetic mutations that results in heterogeneous clinical phenotype and outcome. Genetic studies have enabled the identification of a set of recurrently mutated genes which are central to the pathogenesis of MDS and can be organized into a limited number of cellular pathways, including RNA splicing (
Identifiants
pubmed: 34440317
pii: genes12081144
doi: 10.3390/genes12081144
pmc: PMC8392119
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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